Semaglutide
Ozempic · Wegovy
What a well-evidenced compound looks like: dozens of trials, Phase 3 and 4, approved indications that match what it's sold for. Included as the yardstick.
Studied for fat loss
545
Registered trials
Liraglutide
Victoza · Saxenda · NN2211
The previous generation of GLP-1 drug, approved since 2010. Included as a reference point for what a mature evidence base looks like.
Studied for fat loss
419
Registered trials
Tirzepatide
Mounjaro · Zepbound
The other yardstick. When something works, the trial record looks like this — not like a blank page.
Studied for fat loss
207
Registered trials
Cagrilintide
AM833 · NNC0174-1213
An amylin analogue in Phase 3 for obesity, mostly studied in combination with semaglutide. Not approved anywhere.
Studied for fat loss
39
Registered trials
Mazdutide
IBI362 · LY3305677
A GLP-1/glucagon dual agonist approved in China and still investigational in the US.
Studied for fat loss
37
Registered trials
Survodutide
BI 456906
An investigational GLP-1/glucagon dual agonist in Phase 3 for obesity and liver disease.
Studied for fat loss
31
Registered trials
Retatrutide
LY3437943 · triple agonist
A triple-receptor agonist in Phase 3 for obesity and diabetes. Not approved for anything yet, and already sold online.
Studied for fat loss
19
Registered trials
Tesamorelin
Egrifta
Genuinely FDA-approved — for one specific condition in people with HIV. That approval does not extend to the general anti-aging use it's sold for.
Studied for fat loss
16
Registered trials
Tesofensine
NS 2330
A triple monoamine reuptake inhibitor rather than a peptide, despite being sold in peptide catalogues.
Studied for fat loss
13
Registered trials
CJC-1295
Modified GRF (1-29) · DAC:GRF
One human trial ever registered, and it was stopped early. The registry does not say why.
Studied for fat loss
1
Registered trials
Ibutamoren
MK-677 · MK-0677 · LUM-201 · Nutrobal
A growth-hormone secretagogue, widely mislabelled as a SARM. Studied mostly for growth hormone deficiency rather than the uses it is sold for.
Trials, but not for fat loss
13
Registered trials
Ipamorelin
Growth hormone secretagogue
Both completed human trials studied bowel movement after surgery. Neither studied muscle, fat, or aging.
Trials, but not for fat loss
2
Registered trials
Melanotan II
MT-2
One registered human trial, for vitiligo — not the tanning or libido uses it is sold for.
Trials, but not for fat loss
1
Registered trials
5-Amino-1MQ
NNMT inhibitor
An NNMT inhibitor, not a peptide. Widely sold for fat loss and longevity; zero registered human trials.
No registered trial
0
Registered trials
GHRP-2
Growth Hormone Releasing Peptide-2 · Pralmorelin
Sold alongside GHRP-6 in nearly identical stacks. Zero registered human trials.
No registered trial
0
Registered trials
AOD-9604
Anti-Obesity Drug 9604 · HGH fragment 176-191
A growth-hormone fragment sold for fat loss. Zero registered human trials under this name.
No registered trial
0
Registered trials
GHRP-6
Growth Hormone Releasing Peptide-6
A staple of growth-hormone peptide stacks sold online. Zero registered human trials.
No registered trial
0
Registered trials
Adipotide
FTPP · Prohibitin-TP01
Marketed for fat loss on the basis of primate studies. Zero registered human trials.
No registered trial
0
Registered trials
—Read this
Marketed for is not tested for
A compound can be sold for fat loss and studied for something else entirely — that is the most common pattern on this site, not the exception. A row saying "trials, but not for fat loss" means registered studies exist and none of them asked this question. It is not a claim that the compound does nothing.