What it's sold for
- Weight loss
- Blood sugar control
- Cardiovascular risk
What has actually been tested
- Obesity
- Diabetes Mellitus, Type 2
- Diabetes
- Type 2 Diabetes
- Overweight
- Healthy
- Obesity & Overweight
- Healthy Volunteers
Is it studied for what it's sold for?
Each claim below is matched against the condition and title fields of every registered trial. Not listed means no trial names it as a studied condition — not that it has been disproven, and not that no trial touches it indirectly.
Studied
Weight loss
Studied
Blood sugar control
Studied
Cardiovascular risk
Every trial on record
Every registered human study we can find for Semaglutide. Click any ID to read the original record — we would rather you checked us than trusted us.
| Trial ID | Title | Condition | Phase | Status | Enrolled |
|---|---|---|---|---|---|
| NCT05569772 | Semaglutide for the Treatment of Glucose Intolerance in Women With Prior Gestational Diabetes | Glucose Intolerance After a Recent History of Gestational Diabetes | Phase 3 | Recruiting now | 252 |
| NCT05119179 | Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes | PreDiabetes | Phase 4 | Recruiting now | 300 |
| NCT06003153 | GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH | Genetic Predisposition, Metabolic Diseases | Phase 4 | Recruiting now | 125 |
| NCT06338553 | GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab | Type 1 Diabetes | Phase 1 | Recruiting now | 24 |
| NCT06396416 | Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2 | Obesity, Chronic Kidney Disease | Phase 4 | Recruiting now | 60 |
| NCT06715514 | Menopausal Hormone Therapy, GLP-1 Agonists, and Glucose and Energy Homeostasis in Postmenopausal Women With Diabetes | Menopause, Type 2 Diabetes | Not phased | Recruiting now | 96 |
| NCT07613437 | GLP-1 Receptor Agonist in Primary Intracerebral Hemorrhage: A Phase 2 Randomized Trial | Intracerebral Hemorrhage | Phase 2 | Not yet recruiting | 200 |
| NCT07165158 | The Effect of Semaglutide on Bone Health | Osteoporosis, Osteoporosis Fracture | Phase 4 | Not yet recruiting | 150 |
| NCT07030621 | Efficacy of Semaglutide in Improving Neurological Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke: A Randomized Double-Blind Controlled Trial | Acute Ischemic Stroke | Phase 3 | Not yet recruiting | 436 |
| NCT07651319 | Interleukine-2 (IL-2) Plus Semaglutide in Alzheimer's Disease | Alzheimer Dementia (AD) | Phase 2 | Recruiting now | 30 |
| NCT05390892 | PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes | Type2Diabetes, ASCVD | Phase 4 | Recruiting now | 6000 |
| NCT07325500 | Incretin Microdosing for Cardiometabolic Health in People With HIV | Weight Gain | Phase 2 | Recruiting now | 30 |
| NCT07570810 | Efficacy, Safety, and Tolerability of CS0159 Combined With Semaglutide in MAFLD Patients With Obesity and T2DM | Type 2 Diabetes, Obesity | Not phased | Not yet recruiting | 30 |
| NCT07581145 | Effect of Semaglutide on Healing of Foot Ulcers in Type 2 Diabetes Patients | Foot Ulcer Due to Type 2 Diabetes Mellitus | Phase 3 | Recruiting now | 52 |
| NCT06548490 | GLP-1R Agonist Treatment for Opioid Use Disorder | Opioid Use Disorder, Opioid Abuse and Addiction | Phase 2 | Recruiting now | 200 |
| NCT07204249 | Glutide for Ending Methamphetamine | Methamphetamine-dependence | Phase 2 | Recruiting now | 162 |
| NCT07227948 | Repurposing Semaglutide for the Treatment of Cocaine Use Disorder | Cocaine Use Disorder | Phase 2 | Recruiting now | 75 |
| NCT07627191 | GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular Cancer | Pancreatic Cancer, Colorectal Cancer | Phase 1 | Not yet recruiting | 30 |
| NCT06894784 | A Clinical Trial to Evaluate The Effects of Semaglutide and Empagliflozin Combined to Automated Insulin Delivery on Diabetes Control in Adults Living With Type 1 Diabetes | Diabetes Type 1 | Phase 3 | Recruiting now | 36 |
| NCT06616961 | Efficacy and Safety of Semaglutide for Weight Loss in Overweight or Obese Adults in Bangladesh With or Without Type 2 Diabetes Mellitus | Obesity, Type 2 Diabetes Mellitus (T2DM) | Phase 3 | Not yet recruiting | 480 |
| NCT07617155 | GLP-1 Agonists for Prevention of Recurrent Hypertriglyceridemic Acute Pancreatitis | Hypertriglyceridemia Induced Acute Pancreatitis, Recurrent Acute Pancreatitis | Phase 4 | Not yet recruiting | 396 |
| NCT07411378 | Testing the Efficacy, Safety, and PK of 20E in Patients With Obesity Who Are Starting Treatment With the GLP-1 Agonist Semaglutide for Weight Loss. | Muscle Wasting, Obesity & Overweight | Phase 2 | Not yet recruiting | 164 |
| NCT07179120 | Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm Health | Obesity-related Male Infertility | Phase 2 | Not yet recruiting | 180 |
| NCT07485062 | Exercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes | Type 2 Diabetes, Cognitive Decline in Older Adults | Phase 4 | Not yet recruiting | 164 |
| NCT06885736 | LEAN Mass Preservation With Resistance Exercise and Protein During Semaglutide/Tirzepatide Therapy | Obesity | Not phased | Recruiting now | 232 |
| NCT07462663 | SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer | Endometrial Cancer, Endometrial Cancer Stage I | Phase 4 | Not yet recruiting | 80 |
| NCT06897475 | A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide | Type 2 Diabetes | Phase 2 | Recruiting now | 240 |
| NCT07282769 | Semaglutide (Wegovy) Treatment for Trichotillomania | Trichotillomania (Hair-Pulling Disorder), Trichotillomania | Phase 2 | Not yet recruiting | 10 |
| NCT06633783 | A Phase III Study Comparing the Weight Loss Effects of Semaglutide Injection and Wegovy® | Obesity | Phase 3 | Not yet recruiting | 370 |
| NCT07297589 | Epicardial Cardiac Fat-CT (EPIC-CT) | STEMI - ST Elevation Myocardial Infarction, Epicardial Fat | Phase 3 | Recruiting now | 136 |
| NCT07139548 | A Study of RAY1225 Versus Semaglutide as Add-on Therapy to Oral Antidiabetic Drugs in Participants With Type 2 Diabetes | T2DM | Phase 3 | Not yet recruiting | 600 |
| NCT07150975 | Phase III Clinical Study Comparing the Efficacy and Safety of GZR18 Injection and Semaglutide (Wegovy®) in Adult Obese or Overweight Subjects | Obesity/Overweight in Adult | Phase 3 | Recruiting now | 420 |
| NCT07592546 | Translational Health Research Into Vascular and Neurocognitive Effects of Weight Loss | Class I/II Obesity | Phase 4 | Not yet recruiting | 240 |
| NCT06072963 | COMMETS- Combination MCI Metabolic Syndrome | Alzheimer Disease, Mild Cognitive Impairment | Phase 2 | Recruiting now | 80 |
| NCT07253285 | A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight | Overweight, Obesity | Phase 3 | Recruiting now | 460 |
| NCT05586802 | Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome | Klinefelter Syndrome | Phase 3 | Recruiting now | 150 |
| NCT06863363 | PEG-rhGH and Semaglutide Combination Therapy in Non-Diabetic Obese Adults | Non-diabetic Obesity | Phase 4 | Not yet recruiting | 212 |
| NCT06717698 | A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease | Chronic Kidney Disease | Phase 2 | Recruiting now | 465 |
| NCT05780905 | Effects of Semaglutide on Intracranial Blood Flow and Brain-Barrier Permeability in Type-2 Diabetes | Diabetes Mellitus, Type 2, Stroke (CVA) or Transient Ischemic Attack | Phase 4 | Recruiting now | 50 |
| NCT06788626 | Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke After Endovascular Treatment | Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Not yet recruiting | 390 |
| NCT07668388 | A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 2 | Recruiting now | 300 |
| NCT07242534 | Effect of Semaglutide on Embryo Quality in Overweight and Obese Patients Undergoing In Vitro Fertilization. | Infertility, Obesity | Phase 4 | Recruiting now | 62 |
| NCT07446998 | Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight Loss | Obesity & Overweight, Mobility Disability | Phase 2 | Recruiting now | 200 |
| NCT07430332 | GLP-1 RA for Stage 1 Type 1 Diabetes | Stage 1 Diabetes Mellitus, Type 1 | Phase 2 | Not yet recruiting | 15 |
| NCT07021937 | Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity | Obesity/Therapy | Phase 3 | Not yet recruiting | 120 |
| NCT07295223 | Effect of Glp-1 and Antidiabetic sgLT2 Agents for myoCardial infarcTion and Ultrasensitive Inflammatory Surveillance (GALACTUS Trial) | Acute Myocardial Infarction With ST Elevation | Phase 3 | Recruiting now | 44 |
| NCT06318442 | The GAPSID Study - How GLP-1 Analogues Prevent Steroid-Induced Diabetes | Steroid-Induced Diabetes, Steroid Induced Hyperglycemia | Not phased | Recruiting now | 60 |
| NCT07361874 | IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion | Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS) | Not phased | Recruiting now | 75 |
| NCT07589322 | Comparative Observation of Metabolic and Pharmacologic Adipose Remodeling With Enhanced Incretin AgonisTs | Obesity and Metabolic Syndrome | Not phased | Recruiting now | 120 |
| NCT07391267 | Pathogenesis of Chronic Kidney Disease Associated With Metabolic Dysfunction- Associated Fatty Liver Disease (MAFLD) and Treatment Response of Oral Semaglutide. | Chronic Kidney Diseases, MAFLD | Not phased | Not yet recruiting | 90 |
| NCT06989203 | Protein Supplementation Intervention on Body Weight | Obesity, Weight Loss | Not phased | Recruiting now | 140 |
| NCT07713992 | Efficacy and Safety of Mazdutide in Patients With Type 2 Diabetes Mellitus and Moderate to Severe Nonalcoholic Fatty Liver Disease Previously Treated With Semaglutide | Type 2 Diabetes Mellitus (T2DM), Nonalcoholic Fatty Liver Disease (NAFLD) With History of Diabetes Melitus | Not phased | Not yet recruiting | 72 |
| NCT07668414 | A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide | Overweight, Obesity | Phase 3 | Not yet recruiting | 650 |
| NCT07272343 | The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes | Type 2 Diabetes Mellitus (T2DM), Semaglutide | Phase 4 | Recruiting now | 100 |
| NCT07536516 | Measurement of Ocular Blood Flow and Retinal Oxygen Extraction in Diabetic Patients | Diabetes Mellitus | Not phased | Recruiting now | 20 |
| NCT07478653 | MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease | Obesity, Dental Care for Children | Not phased | Not yet recruiting | 50 |
| NCT05305794 | Effect of Weekly GLP1 Agonist Treatment in "Double Diabetes" | Double Diabetes | Phase 3 | Recruiting now | 76 |
| NCT07254572 | Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes | Coronary Artery Disease, PreDiabetes | Phase 4 | Recruiting now | 300 |
| NCT06082063 | Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes | Cardiovascular Diseases, Heart Failure | Phase 3 | Recruiting now | 2000 |
| NCT07415954 | A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 2 | Recruiting now | 270 |
| NCT07064486 | A Study of BGM0504 in Participants With Type 2 Diabetes in Indonesia | Type 2 Diabetes (T2DM) | Phase 3 | Recruiting now | 477 |
| NCT07724340 | A Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweight or Obesity | Adults With Overweight/Obesity and Type 2 Diabetes | Phase 2 | Recruiting now | 150 |
| NCT07284979 | Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes | Obesity | Phase 3 | Recruiting now | 1200 |
| NCT07314528 | Evaluating the Impact of GLP-1 Receptor Agonists With Total Neoadjuvant Therapy in Rectal Cancer | Rectal Cancer Patients, Obesity &Amp; Overweight | Phase 2 | Not yet recruiting | 42 |
| NCT06575738 | Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents | Obesity, Adolescent Obesity | Phase 1 | Recruiting now | 40 |
| NCT07400107 | AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight | Obesity, Overweight | Phase 3 | Not yet recruiting | 1000 |
| NCT07317115 | Side-to-Side Duodeno-ileostomy Versus Semaglutide in Adults With Obesity and Type 2 Diabetes | Obesity (Disorder), Obesity & Overweight | Not phased | Recruiting now | 20 |
| NCT06908694 | Investigation of GLP1-Receptor Agonists in Men With Prostate Cancer Taking Androgen Deprivation Therapy | Prostate Cancer | Phase 4 | Recruiting now | 20 |
| NCT07554417 | Combatting Muscle Loss in Obese Adult Patients on GLP-1 Medications Through Dietary Counseling and Exercise During Treatment Evaluates Whether a 12-week Exercise and Individualized Nutrition Program Can Reduce Muscle and Bone Loss and Improve Strength, Fitness, and Function in Obese Adults on GLP-1 | GLP - 1, Obesity & Overweight | Phase 4 | Not yet recruiting | 20 |
| NCT06497595 | Lifestyle Intervention to Reduce the Risk of Sarcopenia in Adults With Diabetes & Obesity Treated With Semaglutide | Type 2 Diabetes Mellitus in Obese | Not phased | Recruiting now | 60 |
| NCT06909006 | Semaglutide Treatment in Type 1 Diabetes | Obesity in Diabetes, Obesity/Therapy | Phase 3 | Not yet recruiting | 122 |
| NCT06461377 | The Ameliorative Effects of GLP-1RA on Diabetic Cardiac Autonomatic Neuropathy | Type 2 Diabetes, Diabetes With Diabetic Autonomic Neuropathy (Diagnosis) | Phase 4 | Recruiting now | 50 |
| NCT07184086 | A Study to See How Metabolism is Influenced by Weight Loss Due to Intervention With Cagrilintide and Semaglutide Compared to Diet | Obesity | Phase 1 | Recruiting now | 80 |
| NCT07614412 | SHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes. | Type 1 Diabetes Mellitus | Phase 2 | Not yet recruiting | 240 |
| NCT05819138 | Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes | Diabetes Mellitus, Type 1 | Phase 3 | Recruiting now | 60 |
| NCT05822609 | Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes | Diabetic Kidney Disease, Type 1 Diabetes | Phase 2 | Recruiting now | 60 |
| NCT07090343 | Semaglutide in Patients Undergoing Transcatether Aortic Valve Replacement | Aortic Stenosis, Heart Failure | Phase 3 | Not yet recruiting | 826 |
| NCT07223242 | Tailored Exercise Training Study Among Adults With HFpEF | HFpEF - Heart Failure With Preserved Ejection Fraction, Diabetic Cardiomyopathies | Phase 3 | Recruiting now | 120 |
| NCT07465965 | A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults | Overweight, Obesity | Phase 1 | Recruiting now | 60 |
| NCT07073053 | The Role of Glucagon-Like Peptide-1 Receptor Agonists in Coronary Artery Diseases and Their Potential Mechanisms | Glucagon-Like Peptide-1 Receptor Agonists, Type 2 Diabetes | Phase 4 | Not yet recruiting | 60 |
| NCT07502508 | Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy | Type 2 Diabetes | Phase 2 | Recruiting now | 60 |
| NCT07547878 | Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD) | Chronic Kidney Disease, Type 2 Diabetes | Phase 4 | Not yet recruiting | 64 |
| NCT07599046 | Fecal Microbiota Transplantation (FMT) Combined With Calorie-Restricted Diet and Semaglutide in Patients With Obesity and Type 2 Diabetes | Obesity Type 2 Diabetes Mellitus | Not phased | Not yet recruiting | 20 |
| NCT06499857 | Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation | Overweight or Obesity, Atrial Fibrillation | Phase 3 | Recruiting now | 200 |
| NCT07523633 | Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder | Cannabis Use Disorder, Cannabis Use Disorders | Phase 2 | Recruiting now | 100 |
| NCT07065383 | Rebalancing the Fat Content of the Heart and Muscles | Diabetes Mellitus Type 2 | Not phased | Recruiting now | 60 |
| NCT06555146 | Semaglutide's Effect on Renal Hemodynamics and Function in Patients With Type 2 Diabetes Mellitus and Nephropathy | Diabetes Mellitus, Type 2, Kidney Disease, Chronic | Not phased | Not yet recruiting | 15 |
| NCT07213466 | Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder | Bipolar I Disorder, Bipolar II Disorder | Phase 4 | Recruiting now | 100 |
| NCT07633639 | GLP-1 Therapy After Bariatric Surgery in Chinese Patients With Obesity | Obesity | Not phased | Recruiting now | 200 |
| NCT06410352 | Effectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome | Metabolic Syndrome | Phase 4 | Recruiting now | 220 |
| NCT07036172 | Efficacy and Safety of Semaglutide Injection Vs WEGOVY® in Chinese Obese Patients | Obesity Control | Phase 3 | Recruiting now | 460 |
| NCT06989177 | Probiotic Intervention on Body Weight | Obesity, Homeostasis | Not phased | Recruiting now | 140 |
| NCT06913023 | Semaglutide for the Prevention Of Post-Transplant Diabetes Mellitus | Kidney Transplant Recipient | Phase 3 | Not yet recruiting | 74 |
| NCT06691243 | Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV | Cocaine Use Disorder, HIV | Phase 2 | Recruiting now | 40 |
| NCT07010432 | The Role of the Amylin Analogue Cagrilintide in Bone Metabolism | Obesity | Phase 1 | Recruiting now | 144 |
| NCT07187856 | Phase 2 Randomized Study of PG-102 vs Placebo and Semaglutide in Type 2 Diabetes Mellitus | Type 2 Diabetes Mellitus (T2DM) | Phase 2 | Not yet recruiting | 80 |
| NCT07027969 | Metabolic Surgery for Atrial Fibrillation Elimination | Atrial Fibrillation, Obesity and Obesity-related Medical Conditions | Phase 4 | Not yet recruiting | 100 |
| NCT06986993 | Impact of Semaglutide on Tobacco Use and Related Health Behaviors | Tobacco Use | Phase 4 | Recruiting now | 40 |
| NCT06762314 | Efficacy and Safety of Empagliflozin or Semaglutide in Overweight/Obese Patients With Type 1 Diabetes | Diabetes | Phase 2 | Recruiting now | 105 |
| NCT07628985 | BALANCE-DM2 Study of Bofanglutide in Adults With Type 2 Diabetes | Type 2 Diabetes Mellitus (T2DM) | Phase 3 | Not yet recruiting | 374 |
| NCT05938712 | The Efficacy, Mechanism & Safety of Sodium Glucose Co-Transporter-2 Inhibitor & Glucagon-Like Peptide 1 Receptor Agonist Combination Therapy in Kidney Transplant Recipients | Kidney Transplant Recipients | Phase 2 | Recruiting now | 20 |
| NCT07563699 | Safety, Tolerability and Efficacy of Semaglutide Depot in Subjects With Type-2 Diabetes Mellitus | Diabete Type 2 | Phase 2 | Not yet recruiting | 24 |
| NCT06613854 | Effect of Early Combination Antihyperglycemic Treatment on Metabolic Control in Individuals With Type 2 Diabetes | Type 2 Diabetes Mellitus (T2DM) | Phase 4 | Recruiting now | 90 |
| NCT06975111 | Focusing on the Menopausal Transition to Improve Mid-Life Women's Health | Menopause, Menopause Hot Flashes | Phase 3 | Recruiting now | 200 |
| NCT06716216 | A Study of BGM0504 in Participants with Type 2 Diabetes | Type 2 Diabetes Mellitus (T2DM) | Phase 3 | Recruiting now | 537 |
| NCT07401992 | Effects of Semaglutide on Clinical Outcomes and Metabolic Inflammation in Psoriasis | Psoriasis (PsO), Obesity & Overweight | Phase 4 | Recruiting now | 62 |
| NCT06825793 | Semaglutide's Weight Loss Effects in Obesity | Obesity | Not phased | Not yet recruiting | 56 |
| NCT07091500 | Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity | Obesity, Skeletal Muscle | Not phased | Recruiting now | 40 |
| NCT07314684 | GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM | T2DM (Type 2 Diabetes Mellitus) | Phase 4 | Recruiting now | 80 |
| NCT06896981 | Semaglutide in Women With Polycystic Ovary Syndrome and Obesity | Polycystic Ovary Syndrome (PCOS) Women, Obesity | Phase 3 | Recruiting now | 30 |
| NCT06184633 | DUTCH Weight Control in Atrial Fibrillation Study | Atrial Fibrillation, Obesity | Phase 4 | Recruiting now | 280 |
| NCT06541509 | Mechanisms of Semaglutide Therapy in Heart Failure Patients | Heart Failure, Obesity | Phase 2 | Recruiting now | 10 |
| NCT06387199 | Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide | Type 1 Diabetes, Diabetes Mellitus | Phase 3 | Recruiting now | 26 |
| NCT07101939 | A Study of the Effect of (S)-Pindolol Benzoate (ACM-001.1) on Lean Body Mass (LBM) in Obese Patents During (PROACT 1), and Post-semaglutide Therapy (PROACT 2) | Obesity, Muscle Loss | Phase 2 | Recruiting now | 120 |
| NCT05702931 | Semaglutide Treatment for Hyperglycaemia After Renal Transplantation | Hyperglycemia, Renal Transplant Complication Primary Non-Function | Phase 4 | Recruiting now | 104 |
| NCT07251556 | GLP-1 Receptor Agonists in Non-diabetic Patients With Psoriatic Arthritis | Psoriasis Arthritis | Phase 4 | Not yet recruiting | 40 |
| NCT07539415 | A Phase 1 Clinical Trial to Assess the Safety of DWRX5003 and Relative Bioavailability to DWC202502 and DWC202503 in Healthy Adult Volunteers | Obesity & Overweight, Type 2 Diabetes | Phase 1 | Recruiting now | 72 |
| NCT06449625 | Semaglutide in Auto-HSCT | Intestinal Mucositis, Inflammation | Phase 2 | Not yet recruiting | 40 |
| NCT07200622 | Oral Semaglutide in Patients With Alzheimer's Disease | Alzheimer Disease | Phase 2 | Not yet recruiting | 60 |
| NCT07727473 | Preoperative Semaglutide Prior to Radical Prostatectomy | Prostate Cancer | Phase 1 | Not yet recruiting | 20 |
| NCT07728669 | Digital Dietary Intervention for Patients Receiving GLP-1 Receptor Agonist Therapy | Type 2 Diabetes Mellitus (T2DM), Obesity (Disorder) | Not phased | Recruiting now | 120 |
| NCT04174755 | Semaglutide's Efficacy in Achieving Weight Loss for Those With HIV | Obesity, HIV-1-infection | Not phased | Recruiting now | 80 |
| NCT07249554 | Combination Therapy for Alcohol Use Disorder | Alcohol Use Disorder | Phase 2 | Not yet recruiting | 45 |
| NCT07239570 | A Biomarker-targeted Clinical Trial to Optimize Treatment for Patients With Chronic Kidney Disease | Chronic Kidney Disease(CKD) | Phase 4 | Recruiting now | 125 |
| NCT07728383 | A Proof-of-Concept Study to Evaluate Topical-Lingual Semaglutide in Adults With Obesity | Obesity & Overweight | Phase 4 | Recruiting now | 40 |
| NCT05071898 | Pharmacogenetics of Response to GLP1R Agonists | Obesity, Diabetes Type 2 | Phase 1 | Recruiting now | 600 |
| NCT04990024 | The Effect of Different Diets on Arterial Stiffness in Obese Patients on Semaglutide | Obesity, Weight Loss | Not phased | Recruiting now | 60 |
| NCT07254715 | Effect of Itopride on Semaglutide Gastroparesis | Semaglutide-Induced Gastric Motility, Anesthesia | Phase 4 | Recruiting now | 60 |
| NCT05173714 | Sit Less, Interact and Move More (SLIMM) 2 Study | Chronic Kidney Diseases, Obesity | Phase 2 | Recruiting now | 156 |
| NCT05356104 | GLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD) | Cerebral Small Vessel Disease | Phase 2 | Recruiting now | 110 |
| NCT07135245 | Improved Treatment and Monitoring of Alzheimer's Disease | Alzheimer Disease (AD) | Phase 2 | Not yet recruiting | 180 |
| NCT07495020 | The Transit Bipartition With the Use of a Metallic Anastomosis Clip and Circular Fundocorporeal Gastroplication | Type 2 Diabetes Mellitus (T2DM), Obesity & Overweight | Not phased | Recruiting now | 90 |
| NCT06411210 | Obesity Complicating Type 1 Diabetes: GLP-1 Analogue Anti-obesity Treatment | Diabetes type1, Obesity | Phase 2 | Recruiting now | 54 |
| NCT06981936 | This Randomized Trial Aims to Investigate the Efficacy of Balanced Nutritional Tablets-Comprehensive Multivitamin and Mineral Supplements- in Preventing Micronutrient Deficiencies Among Patients Utilizing GLP-1 RAs for Weight Loss in Comparison to a Placebo Control | Micronutrient Deficiencies | Phase 4 | Recruiting now | 150 |
| NCT06937060 | Effect of Semaglutide in Patients With Psoriasis and Obesity | Psoriasis (PsO), Obesity and Overweight | Phase 3 | Recruiting now | 14 |
| NCT07294950 | Impact of Semaglutide Withdrawal on Cardiometabolic Profile and Physiology of Energy Balance: Recovery Effects After Semaglutide Termination | Obesity (Disorder), Weight Change | Phase 3 | Recruiting now | 98 |
| NCT06557811 | Effect of Oral Semaglutide on Epicardial and Pericoronary Adipose Tissues in Type 2 Diabetes After Myocardial Infarction | Diabetic Patients, Acute Myocardial Infarction | Phase 4 | Not yet recruiting | 88 |
| NCT06431308 | Nutritional Therapy to Incretin-based Anti-obesity Medications in the Management of Gastrointestinal Adverse Events | Obesity; Drug | Not phased | Recruiting now | 120 |
| NCT06446531 | Prevention of Progression of Prediabetes, Obesity and CV Risk | Pre-Diabetes, Weight, Body | Phase 1 | Recruiting now | 64 |
| NCT07221214 | GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV | HIV, Alcohol | Phase 2 | Recruiting now | 200 |
| NCT07244458 | Dietary Peanuts and Nutrition-Related Outcomes | Dietary Change, Obesity & Overweight | Not phased | Recruiting now | 64 |
| NCT07058155 | Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease | Liver Cirrhoses, Portal Hypertension Related to Cirrhosis | Phase 4 | Recruiting now | 70 |
| NCT05424003 | Randomized Double Blinded Placebo-Controlled w/Semaglutide to Prevent Weight Gain After Liver Transplant | NAFLD | Phase 2 | Recruiting now | 50 |
| NCT06903923 | Bone Metabolism in 12-21 Year Olds Undergoing Glucagon Like Peptide (GLP)-1 Receptor Agonist Therapy | Obesity in Children, Bone Strength | Phase 2 | Recruiting now | 120 |
| NCT06706284 | Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes | Spinal Cord Injuries, Type 2 Diabetes | Phase 4 | Recruiting now | 50 |
| NCT04873050 | Treatment to Regress to Normoglycemia in Women with a Recent History of GDM | Pre Diabetes, Postpartum Disorder | Phase 4 | Recruiting now | 102 |
| NCT07513168 | Low-Dose Semaglutide for Weight Loss in Obese Non-Diabetic Pakistani Adults | Obesity, Weight Reduction | Phase 4 | Recruiting now | 60 |
| NCT07195994 | A Clinical Trial to Examine the Efficacy and Safety of an Investigational Product With and Without Use of Semaglutide on Glycemic Response in Adults With Prediabetes or Type 2 Diabetes | Prediabetes / Type 2 Diabetes | Not phased | Recruiting now | 90 |
| NCT07035704 | Prevent and Reverse Obesity in Children, Adolescents and Young Adults | Overweight (BMI > 25) | Not phased | Not yet recruiting | 200 |
| NCT07392151 | Reversal to Normoglycemia by Treating Prediabetes | Prediabetes, Chronic Coronary Syndrome | Phase 3 | Not yet recruiting | 158 |
| NCT07059377 | Semaglutide for Smoking Cessation in Patients With Diabetes | Diabetes Mellitus, Type 2, Nicotine Addiction | Phase 3 | Recruiting now | 100 |
| NCT07017270 | Glucagon-like-peptide-1 Receptor Agonists in Patients Receiving Maintenance Dialysis | Kidney Disease, Chronic, Diabetes | Phase 4 | Recruiting now | 100 |
| NCT04880005 | Digital Individualized and Collaborative Treatment of T2D in General Practice Based on Decision Aid | Diabetes type2 | Not phased | Recruiting now | 400 |
| NCT07275697 | Waiting on Atrial Fibrillation Intervention Therapy (WAIT) Study | Atrial Fibrillation (AF), Obesity & Overweight | Phase 4 | Not yet recruiting | 200 |
| NCT05925959 | Preoperative Weight Loss for Open Abdominal Wall Reconstruction | Abdominal Wall Hernia | Not phased | Recruiting now | 258 |
| NCT07178145 | Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction | Heart Failure Preserved Ejection Fraction, Epicardial Adipose Tissue | Phase 4 | Recruiting now | 192 |
| NCT06287307 | Semaglutide 2.4mg for Low Responders After Bariatric Surgery | Obesity, Obesity, Morbid | Phase 4 | Not yet recruiting | 152 |
| NCT07558863 | Effect of GLP-1RA on Cardiac Autonomic Neuropathy in Type 2 Diabetes | Type 2 Diabetes, Diabetes With Diabetic Autonomic Neuropathy (Diagnosis) | Phase 4 | Recruiting now | 60 |
| NCT07564414 | A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight | Obesity, Type 2 Diabetes | Phase 3 | Recruiting now | 2500 |
| NCT07225816 | Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected) | Obesity | Phase 1 | Recruiting now | 71 |
| NCT07389941 | Semaglutide PrIor to CathEeter Ablation in Patients With Atrial Fibrillation | Atrial Fibrillation (AF) | Phase 4 | Not yet recruiting | 240 |
| NCT07509112 | Semaglutide for Treatment of People With Methamphetamine Use Disorder: the SHIFT Study | Methamphetamine Use Disorder | Phase 2 | Not yet recruiting | 40 |
| NCT07293325 | Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With Obesity | Adults With Simple Obesity | Not phased | Recruiting now | 66 |
| NCT07701460 | Assessing Follow up Trajectories in Eating, Routines, and Weight After GLP-1 | Weight Maintenance | Not phased | Not yet recruiting | 200 |
| NCT07621640 | Brown Adipose Tissue as a Mechanistic Determinant of Semaglutide Treatment Response in Obesity (BAT-Sema Study) | Obesity, Metabolic Syndrome | Not phased | Not yet recruiting | 80 |
| NCT05340868 | Genetics of the Acute Response to Oral Semaglutide | PreDiabetes, Prediabetic State | Not phased | Recruiting now | 1000 |
| NCT07466017 | A Study of CS060380 Tablets in Patients With MASH and Obesity | Metabolic Dysfunction-associated Steatohepatitis (MASH), Obesity | Phase 2 | Recruiting now | 120 |
| NCT07282613 | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Not yet recruiting | 80 |
| NCT07218354 | Cessation or Reduction of Alcohol Consumption in Veterans: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial to Evaluate the Efficacy and Safety of a GLP-1 Receptor Agonist Semaglutide in U.S. Veterans With Alcohol Use Disorder | Alcohol Use Disorder | Phase 3 | Not yet recruiting | 622 |
| NCT07213323 | Probiotic Intervention for Digestive Health in Obese Patients Initiating GLP-RA Treatment | Obesity &Amp; Overweight, Digestive Disorders | Not phased | Not yet recruiting | 50 |
| NCT07673900 | Semaglutide Delivered Epi-Intradermally by Microarray Patch (VX-201) Versus Subcutaneous Administration in Healthy Overweight and Obese Participants | Overweight and/or Obesity | Phase 1 | Recruiting now | 62 |
| NCT06060392 | Effect of Oral Semaglutide on Liver Fat and Body Composition in Liver Transplant Recipients With Diabetes Mellitus | Liver Transplant; Complications, Diabete Mellitus | Not phased | Recruiting now | 50 |
| NCT06423599 | Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure | Heart Failure With Reduced Ejection Fraction, Obesity | Phase 3 | Recruiting now | 100 |
| NCT05746039 | Feasibility of Semaglutide in Advanced Lung Disease | Obesity, Interstitial Lung Disease | Phase 2 | Recruiting now | 8 |
| NCT06738979 | A Clinical Study Comparing Semaglutide Injection and Wegovy® for Weight Management in Obese Subjects | Obesity | Phase 3 | Not yet recruiting | 408 |
| NCT07662213 | A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus | Type 2 Diabetes Mellitus | Phase 3 | Recruiting now | 1200 |
| NCT07597018 | A Research Study to Compare Blood Levels of Cagrilintide After Multiple Doses of Different Versions of Cagrilintide in Adults With Overweight or Obesity | Obesity, Overweight | Phase 1 | Recruiting now | 234 |
| NCT07336862 | Bariatric Surgery Combined With GLP-1 Receptor Agonists Study | Obesity | Phase 2 | Recruiting now | 200 |
| NCT07728812 | Pragmatic Trial to Study the Cost-Effectiveness of MyPhenome-RX Test to Guide Anti-Obesity Pharmacotherapy | Obesity & Overweight | Not phased | Not yet recruiting | 424 |
| NCT07223983 | Semaglutide (SEMA) for Alcohol Use Disorder (AUD) After Metabolic and Bariatric Surgery (MBS) | Alcohol Use Disorder, Weight Loss | Phase 1 | Recruiting now | 10 |
| NCT06173778 | Semaglutide for Post-Smoking Cessation Weight Management | Obesity, Overweight | Phase 2 | Recruiting now | 197 |
| NCT07622810 | BALANCE-OBS: Bofanglutide (GZR18) Versus Semaglutide in Latin American Adults With Overweight or Obesity | Obesity & Overweight | Phase 3 | Not yet recruiting | 352 |
| NCT07092618 | Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation | Longevity, GLP-1 | Phase 3 | Recruiting now | 150 |
| NCT06734312 | MAINTAIN (Mucosal AblatIoN Therapy After INcretins) | Obesity and Obesity-related Medical Conditions, Obesity and Overweight | Not phased | Recruiting now | 20 |
| NCT06374875 | Fibrosis Lessens After Metabolic Surgery | Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver Disease | Phase 4 | Recruiting now | 120 |
| NCT07527195 | Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscle Health) | Obesity | Phase 1 | Recruiting now | 100 |
| NCT07711548 | Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity? | Obesity & Overweight, Weight Loss Maintenance | Not phased | Not yet recruiting | 292 |
| NCT07639021 | A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity | Obesity | Phase 2 | Recruiting now | 230 |
| NCT07202247 | Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial | Prostate Carcinoma, Recurrent Prostate Carcinoma | Phase 2 | Recruiting now | 60 |
| NCT06807970 | Optimization of Obesity for Total Knee Replacement With Glucagon-like Peptide-1 Receptor Agonist | Osteoarthritis (OA) of the Knee | Phase 1 | Not yet recruiting | 54 |
| NCT06946628 | New Triple Therapy in Newly Diagnosed Type 2 Diabetes | Diabetes Mellitus | Phase 3 | Not yet recruiting | 296 |
| NCT06852391 | JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity | Obesity (Disorder) | Phase 4 | Recruiting now | 74 |
| NCT07642635 | Glucagon-Like Peptide-1 Receptor Agonists to Attenuate Metabolic Risk in Individuals With Duchenne Muscular Dystrophy | Duchenne Muscular Dystrophy (DMD) | Phase 2 | Not yet recruiting | 30 |
| NCT06792422 | A Study Investigating Oral Semaglutide in People with Open-Angle Glaucoma | Primary Open Angle Glaucoma (POAG), Open-Angle Glaucoma | Phase 4 | Recruiting now | 126 |
| NCT07171723 | Studying the Influence of LEAP2 on Integrated Endocrine Control of Eating During Semaglutide Treatment | Obesity &Amp; Overweight | Phase 2 | Recruiting now | 24 |
| NCT06764056 | Characterization and Management of Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) | Metabolic Associated Fatty Liver Disease, Metabolic Associated-dysfunction Steatohepatitis (MASH) | Not phased | Not yet recruiting | 120 |
| NCT07046273 | Phase III Clinical Study on the Efficacy and Safety of Semaglutide and Ozempic® in Patients With Type 2 Diabetes | Type 2 Diabetes (T2DM) | Phase 3 | Not yet recruiting | 496 |
| NCT05501483 | Adipose Tissue Heterogeneity and Its Link to Type 2 Diabetes | Type 2 Diabetes | Not phased | Recruiting now | 60 |
| NCT07364175 | A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults | Hypertension, Obesity & Overweight | Not phased | Recruiting now | 60 |
| NCT06836284 | The Evira Study: Additional Support During Obesity Treatment | Childhood Obesity, Treatment Adherence | Not phased | Recruiting now | 40 |
| NCT07487103 | Efficacy and Safety of QLG1091 vs Rybelsus as add-on to Metformin in Subjects With Type 2 Diabetes | Type 2 Diabetes | Phase 3 | Not yet recruiting | 478 |
| NCT06977438 | GLP-1 Plus Lifestyle for Overall Wellness: Find Your Way Forward | Obesity, Childhood | Phase 4 | Not yet recruiting | 1020 |
| NCT03884075 | Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES) | Non-Alcoholic Steatohepatitis, Non-Alcoholic Fatty Liver Disease | Phase 2 | Recruiting now | 104 |
| NCT06487832 | Effect of GLP1 Receptor Agonist on Brain Insulin Responsiveness | Normal Weight, Overweight and Obesity | Not phased | Recruiting now | 60 |
| NCT06449235 | Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in Bangladesh | Type2diabetes | Phase 4 | Not yet recruiting | 938 |
| NCT05819853 | Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome | PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Obese | Phase 3 | Recruiting now | 80 |
| NCT07374328 | Triple Hypoglycemic Regimens In Patients With Newly Diagnosed Type 2 Diabetes Mellitus | Type 2 Diabetes | Phase 2 | Recruiting now | 240 |
| NCT06639464 | Semaglutide for Helping Opioid Recovery | Opioid Use Disorder | Phase 2 | Recruiting now | 46 |
| NCT07586150 | Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN) | Severe Mental Illness, Depression / Major Depressive Disorder | Not phased | Not yet recruiting | 140 |
| NCT07511543 | Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy | Ischemic Stroke | Phase 3 | Not yet recruiting | 826 |
| NCT05700877 | Screening and Intervention for Subclinical Coronary Artery Disease in Patients With Type 2 Diabetes | Type 2 Diabetes, Cardiovascular Diseases | Phase 4 | Recruiting now | 7300 |
| NCT06830343 | The Safety, Tolerability, and Pharmacokinetics of of SYH9017 in Chinese Participants With Overweight and Obesity | Overweight or Obesity | Phase 1 | Recruiting now | 66 |
| NCT06751589 | A Study of a Weight Loss Intervention in People With Endometrial Cancer | Endometrial Cancer | Phase 1 | Recruiting now | 36 |
| NCT07040592 | Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide | Alcohol Use Disorder (AUD), HIV | Phase 2 | Recruiting now | 30 |
| NCT07136714 | Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity | Major Depressive Disorder | Phase 4 | Recruiting now | 116 |
| NCT06132477 | Impact GLP-1 Agonists Following Bariatric | Morbid Obesity, Metabolic Syndrome | Phase 4 | Recruiting now | 150 |
| NCT06546384 | GLP-1 RA on Alcohol Consumption, Metabolism and Liver Parameters in Patients With Obesity and Fatty Liver Disease | Adiposity, Fatty Liver | Not phased | Not yet recruiting | 64 |
| NCT07653477 | Phase III Study of UBT251 Injection in Patients With Type 2 Diabetes With Inadequate Glycemic Control on Metformin ± Sulfonylurea/SGLT2 Inhibitor Therapy (UNIGUIDE-2) | Type 2 Diabetes | Phase 3 | Not yet recruiting | 956 |
| NCT07244445 | Pistachio Intake and Nutrition-Related Outcomes in Individuals on GLP-1 Therapy | Dietary Change, Obesity & Overweight | Not phased | Recruiting now | 108 |
| NCT07428746 | Investigating the Impact of GLP-1 RA Therapy on Osteosarcopenia in Older Female Adults With Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Not yet recruiting | 20 |
| NCT07483801 | DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies | Cardiovascular Diseases | Phase 4 | Not yet recruiting | 112 |
| NCT07319975 | Effect of Semaglutide and Tirzepatide Combined With Exercise in Obesity | Obesity | Not phased | Not yet recruiting | 48 |
| NCT07446439 | A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use | Nausea and Vomiting, Obesity | Phase 3 | Recruiting now | 280 |
| NCT07430059 | Safety, Tolerability and Pharmacokinetics of a Subcutaneous Semaglutide Implant | Obesity & Overweight | Phase 1 | Not yet recruiting | 20 |
| NCT06934655 | Early Re-Initiation of Semaglutide Post Sleeve Gastrectomy in Youth | Pediatric Obesity, Metabolic and Bariatric Surgery | Phase 3 | Not yet recruiting | 150 |
| NCT07107334 | A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia | Endometrioid Endometrial Adenocarcinoma | Phase 2 | Recruiting now | 20 |
| NCT07226947 | Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment | Obesity, Body Composition | Not phased | Recruiting now | 100 |
| NCT05630586 | Acute Subcutaneous SemaglutidE in Acute Ischemic sTroke | Acute Ischemic Stroke | Phase 2 | Recruiting now | 380 |
| NCT04251156 | Research Study of How Well Semaglutide Works in People Living With Overweight or Obesity. | Overweight, Obesity | Phase 3 | Completed | 375 |
| NCT01923181 | Multiple Dose Trial Examining Dose Range, Escalation and Efficacy of Oral Semaglutide in Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 2 | Completed | 632 |
| NCT03018028 | Dose-response, Safety and Efficacy of Oral Semaglutide Versus Placebo and Versus Liraglutide, All as Monotherapy in Japanese Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 243 |
| NCT06629688 | Semaglutide and Intestinal Iron Absorption | Diabetes Mellitus Type 2, Iron Absorption | Not phased | Completed | 51 |
| NCT05013229 | A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Insulin Glargine Taken Daily With Insulin Aspart (COMBINE 3) | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 679 |
| NCT06282458 | Dose-Finding Study Evaluating Effect on Body Composition of Enobosarm in Patients Taking a GLP-1 for Chronic Weight Mgmt | Muscle Loss, Obesity | Phase 2 | Completed | 168 |
| NCT01766245 | A Randomised, Single Centre, Double-blind, Two-period, Cross-over Trial in Healthy Subjects Investigating the Bioequivalence Between Subcutaneous Injections of Semaglutide Produced by Two Manufacturing Processes | Diabetes, Healthy | Phase 1 | Completed | 28 |
| NCT06409130 | Effects of NNC0194-0499, Cagrilintide, and Semaglutide Alone or in Combinations on Liver Damage and Alcohol Use in People With Alcohol-related Liver Disease | Alcohol-related Liver Disease | Phase 2 | Completed | 270 |
| NCT04639414 | Combined Active Treatment in Type 2 Diabetes With NASH | Type 2 Diabetes, Non-alcoholic Steatohepatitis (NASH) | Phase 4 | Completed | 192 |
| NCT03015220 | Safety and Efficacy of Oral Semaglutide Versus Dulaglutide Both in Combination With One OAD (Oral Antidiabetic Drug) in Japanese Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 458 |
| NCT03574597 | Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity | Overweight, Obesity | Phase 3 | Completed | 17604 |
| NCT05895643 | Does Semaglutide Reduce Alcohol Intake in Patients With Alcohol Use Disorder and Comorbid Obesity? | Alcohol Abuse, Alcohol Addiction | Phase 2 | Completed | 108 |
| NCT04982575 | Research Study to Look at How Well Cagrilintide Together With Semaglutide Works in People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 2 | Completed | 92 |
| NCT04126603 | Impact of Semaglutide on CD34+ EPC and Fat Derived MSC | Diabetes Mellitus, Type 2 | Phase 4 | Completed | 10 |
| NCT05920889 | Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke Treated by Reperfusion Therapies | Stroke, Stroke, Acute | Phase 2 | Completed | 140 |
| NCT04878406 | A Research Study of How the Medicine NNC0480-0389 Taken With Semaglutide Works in the Body of Healthy Japanese Men | Healthy Volunteers Type 2 Diabetes | Phase 1 | Completed | 24 |
| NCT07194317 | A Feasibility Study to Determine the Most Appropriate Digital Dietary Assessment Tool in Patients With Obesity Initiating GLP-1 Receptor Agonist Treatment | Obese Patients | Not phased | Completed | 64 |
| NCT05890976 | Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in Chinese Adults Who Are Above a Healthy Weight Range (OASIS 3) | Overweight, Obesity | Phase 3 | Completed | 200 |
| NCT02863328 | Efficacy and Safety of Oral Semaglutide Versus Empagliflozin in Subjects With Type 2 Diabetes Mellitus | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 822 |
| NCT06579105 | Efficacy, Safety, and Tolerability of Once Daily Oral Administration of AZD5004 Versus Placebo for 26 Weeks in Adults With Type 2 Diabetes Mellitus. | Diabetes Mellitus, Type 2 | Phase 2 | Completed | 406 |
| NCT04916470 | Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes | Heart Failure With Preserved Ejection Fraction (HFpEF) and Diabetes Mellitus, Type 2 | Phase 3 | Completed | 617 |
| NCT04153929 | A Study to Test Whether Different Doses of BI 456906 Are Effective in Treating Adults With Type 2 Diabetes. | Diabetes Mellitus, Type 2 | Phase 2 | Completed | 413 |
| NCT05996848 | A Research Study to See How Well CagriSema Helps People in China With Excess Body Weight Lose Weight | Obesity or Overweight | Phase 3 | Completed | 300 |
| NCT06118008 | A Study of HS-20094 in T2DM Participants | Type 2 Diabetes | Phase 2 | Completed | 54 |
| NCT03936660 | A 12 Month Site Randomized Trial in Adults With Type 2 Diabetes Mellitus and History of Cardiovascular Disease | Diabetes Mellitus, Type 2, Cardiovascular Diseases | Not phased | Completed | 1049 |
| NCT05486065 | A Research Study to Look Into How Well Semaglutide Medicine Works at Different Doses in People With Type 2 Diabetes and Overweight | Diabetes Mellitus, Type 2 | Phase 2 | Completed | 245 |
| NCT05616013 | Safety and Efficacy of Bimagrumab and Semaglutide in Adults Who Are Overweight or Obese | Obesity, Obese | Phase 2 | Completed | 507 |
| NCT02064348 | A Thorough QTc Evaluation of the Effect of Semaglutide on Cardiac Repolarisation in Healthy Subjects | Diabetes, Healthy | Phase 1 | Completed | 168 |
| NCT02249871 | Investigating the Influence of Omeprazole on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects | Diabetes, Healthy | Phase 1 | Completed | 54 |
| NCT05259033 | A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Weekly Semaglutide (COMBINE 2) | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 683 |
| NCT02648204 | Efficacy and Safety of Semaglutide Versus Dulaglutide as add-on to Metformin in Subjects With Type 2 Diabetes. | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 1201 |
| NCT02453711 | Investigation of Safety and Efficacy of Once-daily Semaglutide in Obese Subjects Without Diabetes Mellitus | Metabolism and Nutrition Disorder, Obesity | Phase 2 | Completed | 957 |
| NCT03842202 | A Research Study to Look at How Semaglutide Affects Gastric Emptying in People With Obesity | Overweight, Obesity | Phase 1 | Completed | 72 |
| NCT03987074 | Safety, Tolerability, and Efficacy of Monotherapy and Combination Regimens in Participants With Nonalcoholic Steatohepatitis (NASH) | Nonalcoholic Steatohepatitis | Phase 2 | Completed | 109 |
| NCT05784402 | A Research Study to Compare How Much Semaglutide is Found in the Blood With Different Tablets of Oral Semaglutide in Healthy Participants | Healthy Participants | Phase 1 | Completed | 264 |
| NCT04865744 | The Effect of Semaglutide on Pituitary Function | Healthy | Phase 4 | Completed | 10 |
| NCT04889183 | SeMaglutide and Albuminuria Reduction Trial in Obese Individuals Without Diabetes | Obesity, Albuminuria | Phase 3 | Completed | 125 |
| NCT05144984 | A Research Study Looking at How Well a Combination of the Medicines Semaglutide and NNC0480-0389 Works in People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 2 | Completed | 500 |
| NCT05537233 | ADJUnct Semaglutide Treatment in Type 1 Diabetes | Type 1 Diabetes, Obesity | Phase 2 | Completed | 115 |
| NCT01930188 | Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin and/or TZD in Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 1231 |
| NCT03548935 | STEP 1: Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity | Metabolism and Nutrition Disorder, Overweight or Obesity | Phase 3 | Completed | 1961 |
| NCT04216589 | Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistance, Increased Hepatic Lipids, and Increased Cardiovascular Disease Risk (The SLIM LIVER Study) | HIV Infections, Non-Alcoholic Fatty Liver Disease | Phase 2 | Completed | 51 |
| NCT06642584 | A Research Study Looking at New Protein-based Tablets in Healthy Men - Oral Formulation IV | Healthy Volunteers Type 2 Diabetes | Phase 1 | Completed | 90 |
| NCT05857085 | Novel Therapeutics and Endothelial Dysfunction in T1DM Patients | Endothelial Dysfunction, Diabetes Mellitus, Type 1 | Phase 4 | Completed | 90 |
| NCT05193578 | Home-based Intervention With Semaglutide Treatment Of Neuroleptica-Related Prediabetes | Schizophrenia, Prediabetic State | Phase 2 | Completed | 154 |
| NCT03693430 | Two-year Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity | Overweight, Obesity | Phase 3 | Completed | 304 |
| NCT06739044 | Efficacy and Safety of Semaglutide Injection vs Ozempic® in Patients With Type 2 Diabetes | Type 2 Diabetes | Phase 3 | Completed | 494 |
| NCT05649137 | A Research Study to See How Semaglutide Helps People With Excess Weight and Type 2 Diabetes Lose Weight | Obesity, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 512 |
| NCT05035095 | Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in People Who Are Overweight or Living With Obesity (OASIS 1) | Obesity, Overweight | Phase 3 | Completed | 667 |
| NCT05394519 | A Research Study to See How Well CagriSema Helps People With Type 2 Diabetes and Excess Body Weight Lose Weight | Overweight, Obesity | Phase 3 | Completed | 1200 |
| NCT05891587 | Semaglutide Therapy for Alcohol Reduction - Tulsa | Alcohol Use Disorder | Phase 2 | Completed | 80 |
| NCT05521256 | A Research Study of a New Medicine NNC0113-6856 in Healthy Males | Healthy Volunteers, Type 2 Diabetes | Phase 1 | Completed | 70 |
| NCT05564117 | Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in People Who Have a Body Weight Above the Healthy Range | Overweight, Obesity | Phase 3 | Completed | 307 |
| NCT02970942 | Investigation of Efficacy and Safety of Three Dose Levels of Subcutaneous Semaglutide Once Daily Versus Placebo in Subjects With Non-alcoholic Steatohepatitis. | Hepatobiliary Disorders, Non-alcoholic Steatohepatitis | Phase 2 | Completed | 320 |
| NCT03010475 | A Trial Investigating the Effect of Oral Semaglutide on the Pharmacokinetics of Furosemide and Rosuvastatin in Healthy Subjects | Diabetes, Healthy | Phase 1 | Completed | 41 |
| NCT02863419 | Efficacy and Safety of Oral Semaglutide Versus Liraglutide and Versus Placebo in Subjects With Type 2 Diabetes Mellitus | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 711 |
| NCT03987919 | A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes | Type 2 Diabetes | Phase 3 | Completed | 1879 |
| NCT05548647 | Semaglutide Treatment, Appetite, and Eating Behavior: Long-term Effects | Obesity | Phase 4 | Completed | 120 |
| NCT05087342 | Latino Semaglutide Study | Obesity, Obesity; Drug | Phase 3 | Completed | 119 |
| NCT02845219 | A Trial Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Ethinylestradiol and Levonorgestrel in an Oral Contraceptive Combination Drug in Healthy Postmenopausal Females | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 25 |
| NCT05766709 | A Research Study Comparing Blood Levels of Medicines NNC0194-0499 and Semaglutide Administered as a Combination Formulation Versus Two Separate Formulations | Non-alcoholic Steatohepatitis | Phase 1 | Completed | 53 |
| NCT03061214 | Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin in Subjects With Type 2 Diabetes (SUSTAIN - CHINA MRCT) | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 868 |
| NCT05129891 | A Research Study Looking at New Protein-based Tablets in Healthy Male Participants | Healthy Volunteers, High Blood Cholesterol Levels | Phase 1 | Completed | 384 |
| NCT07539584 | Adiponectin in Patients With Metabolic Disorders | Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD), Type 2 Diabetes Mellitus (T2DM) | Not phased | Completed | 130 |
| NCT04707469 | Research Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 1606 |
| NCT07297238 | Effect of GLP-1 on Intestinal Barrier Function in SBS-IF Patients: A Preliminary Exploration. | Short Bowel Syndrome (SBS), Intestinal Failure | Not phased | Completed | 20 |
| NCT05984238 | A Trial to Evaluate Safety, Feasibility and Efficacy of the ReCET Procedure (EMINENT-2) | Diabetes Mellitus, Type 2 | Not phased | Completed | 33 |
| NCT03989232 | A Research Study to Compare Two Doses of Semaglutide Taken Once Weekly in People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 961 |
| NCT00696657 | A Randomised Controlled Clinical Trial in Type 2 Diabetes Comparing Semaglutide to Placebo and Liraglutide | Diabetes, Diabetes Mellitus, Type 2 | Phase 2 | Completed | 415 |
| NCT06131372 | A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema Compared to Semaglutide, Cagrilintide and Placebo | Chronic Kidney Disease, Type 2 Diabetes | Phase 2 | Completed | 626 |
| NCT06289504 | A Study on How CagriSema Affects Levels of Atorvastatin and Warfarin in the Blood of Participants With Excess Body Weight | Obesity | Phase 1 | Completed | 34 |
| NCT06584916 | A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MAINTAIN) | Obesity, Overweight | Phase 3 | Completed | 376 |
| NCT06221969 | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor | Type 2 Diabetes | Phase 3 | Completed | 1024 |
| NCT04940078 | A Research Study to Compare Blood Levels of Cagrilintide and Semaglutide After Combined Versus Separate Injections in People With Overweight or Obesity | Obesity & Overweight | Phase 1 | Completed | 40 |
| NCT04097600 | A Research Study Comparing Active Drug in the Blood in Healthy Participants Following Dosing of the Current and a New Formulation (D) Semaglutide Tablets | Healthy Volunteers, Type 2 Diabetes | Phase 1 | Completed | 274 |
| NCT04777396 | A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE) | Early Alzheimer's Disease | Phase 3 | Completed | 1840 |
| NCT05788965 | Semaglutide in CFRD | Cystic Fibrosis, Cystic Fibrosis-related Diabetes | Phase 3 | Completed | 8 |
| NCT06648031 | Comparison of the Safety, Efficacy and Pharmacokinetics of DehydraTECH -CBD and DehydraTECH-GLP1 Agonists Alone or in Combination, in Overweight or Obese, Pre- and Type 2 Diabetic Participants | Type2diabetes | Phase 1 | Completed | 148 |
| NCT04873245 | Lifestyle Counseling and Medication for Adolescent Weight Management | Obesity, Childhood | Phase 2 | Completed | 120 |
| NCT05579249 | A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America | Obesity | Phase 4 | Completed | 500 |
| NCT04944992 | A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001) | Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis | Phase 2 | Completed | 145 |
| NCT03021187 | Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Insulin | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 731 |
| NCT04228354 | A Research Study Looking at the Comparability (Bioequivalence) of Two Versions of Semaglutide | Healthy Volunteers, Overweight | Phase 1 | Completed | 28 |
| NCT02128932 | Efficacy and Safety of Semaglutide Once Weekly Versus Insulin Glargine Once Daily as add-on to Metformin With or Without Sulphonylurea in Insulin-naïve Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 1089 |
| NCT04560998 | A Research Study to Compare a Medicine Called Semaglutide Against Placebo in People With Peripheral Arterial Disease and Type 2 Diabetes | Diabetes Mellitus, Type 2, Peripheral Arterial Disease | Phase 3 | Completed | 792 |
| NCT05078255 | The Separate and Combined Effects of Long-term GIP and GLP-1 Receptor Activation in Patients with Type 2 Diabetes | Type 2 Diabetes, Obesity | Not phased | Completed | 61 |
| NCT06608433 | Glucagon-like Peptide-1 Receptor Agnoists for the Assessment of Adrenal Function | Healthy Volunteer Study, HPA | Not phased | Completed | 22 |
| NCT05564104 | A Research Study Looking at How a Single Dose of the Medicine Cagrilintide Works in Participants With Reduced Liver Function and in Healthy Participants With Normal Liver Function and How Cagrilintide is Absorbed and Used by the Body | Hepatic Impairment, Healthy Volunteers | Phase 1 | Completed | 32 |
| NCT02906930 | Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Diet and Exercise Only | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 703 |
| NCT03951753 | A Study of Tirzepatide in Participants With Type 2 Diabetes Mellitus (T2DM) | Diabetes Mellitus, Type 2 | Phase 1 | Completed | 117 |
| NCT03292315 | Once Weekly GLP-1 in Persons With Spinal Cord Injury | Spinal Cord Injuries, Insulin Resistance | Phase 4 | Completed | 5 |
| NCT02877355 | Investigation of the Effect of Upper Gastrointestinal Disease on the Pharmacokinetics of Oral Semaglutide in Subjects With Type 2 Diabetes. | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 55 |
| NCT02147431 | A Trial Investigating the Effect of Semaglutide on Hypoglycaemic Counterregulation Compared to Placebo in Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 38 |
| NCT03288740 | A Trial to Assess the Pharmacokinetics, Safety and Tolerability of Semaglutide in Healthy Chinese Subjects | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 36 |
| NCT03498001 | Effects of GLP-1 Agonists on CArdiac Steatosis Evaluated by Magnetic Resonance Imaging | Type II Diabetes | Not phased | Completed | 42 |
| NCT05520775 | Semaglutide for Alcohol Use Disorder | Alcohol Use Disorder, Cigarette Smoking | Phase 2 | Completed | 48 |
| NCT05689099 | A Research Trial Looking at the Comparability of 2 Different Concentrations of Semaglutide for the 0.5 Milligram (mg) Dose | Diabetes Mellitus, Type 2, Healthy Participants | Phase 1 | Completed | 20 |
| NCT05478252 | A Research Study to Compare Two Semaglutide Medicines in People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 388 |
| NCT02243098 | Investigating the Influence of Semaglutide on the Pharmacokinetics of Single Doses of Atorvastatin and Digoxin in Healthy Subjects | Diabetes, Healthy | Phase 1 | Completed | 31 |
| NCT06475586 | Effect of Semaglutide on the Psoriatic Lesions in Patients With Type 2 Diabetes Mellitus | Psoriasis Vulgaris, Diabetes Type 2 | Phase 4 | Completed | 30 |
| NCT06400615 | Study That Tests AD109 in Patients Taking GLP-1 Drugs | OSA | Phase 2 | Completed | 40 |
| NCT03548987 | Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity | Metabolism and Nutrition Disorder, Obesity | Phase 3 | Completed | 902 |
| NCT03985384 | Semaglutide Treatment On Coronary Progression | Type 2 Diabetes, Coronary Artery Disease | Phase 4 | Completed | 140 |
| NCT04143945 | A Study Comparing the Injection Site Pain Experience After the Injection of Semaglutide B and Semaglutide D With 2 Different Injection Pens, a Compound for the Treatment of Type 2 Diabetes and Obesity | Healthy Volunteers Diabetes Mellitus, Type 2, Healthy Volunteers Overweight | Phase 2 | Completed | 104 |
| NCT03811574 | STEP 6: Research Study Investigating How Well Semaglutide Works in People Living With Overweight or Obesity | Overweight, Obesity | Phase 3 | Completed | 401 |
| NCT03689374 | A Research Study to Compare Semaglutide to Insulin Aspart, When Taken Together With Metformin and Insulin Glargine, in People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 2274 |
| NCT06804603 | A Study to Measure the Effects of Using Tradipitant on Nausea and Vomiting After GLP-1R Agonist Use | Obesity | Phase 2 | Completed | 124 |
| NCT06027567 | The Effect of an Anti-obesity Drug, Semaglutide, as Treatment in New-onset Idiopathic Intracranial Hypertension (IIH) Compared to Standard Weight Management (Dietician) With Regards to Change in Weight and Intracranial Pressure | Idiopathic Intracranial Hypertension, Intracranial Pressure | Phase 4 | Completed | 38 |
| NCT00833716 | Effect of Renal Impairment on the Pharmacokinetics of NN9535 | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 62 |
| NCT06390501 | The Effect of Weekly Semaglutide Treatment on Energy Expenditure | Obesity; Drug | Not phased | Completed | 60 |
| NCT05046873 | A Research Study Looking Into Blood Levels of Semaglutide and NNC0480-0389 When Given in the Same Injection or in Two Separate Injections in Healthy People | Diabetes Mellitus, Type 2 | Phase 1 | Completed | 16 |
| NCT02849080 | Efficacy and Safety of Oral Semaglutide Using a Flexible Dose Adjustment Based on Clinical Evaluation Versus Sitagliptin in Subjects With Type 2 Diabetes Mellitus. | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 504 |
| NCT02210871 | Investigating the Pharmacokinetics, Safety and Tolerability After a Single Subcutaneous Injection of Semaglutide in Subjects With Mild, Moderate or Severe Hepatic Impairment Compared to Subjects With Normal Hepatic Function | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 44 |
| NCT04259801 | First Research Study to Look at How Two Medicines, NNC0480-0389 and Semaglutide, Work Together in Healthy People, in People With High Body Weight and in People With Diabetes | Healthy Volunteers, Overweight | Phase 1 | Completed | 152 |
| NCT04969939 | A Research Study to Investigate How Well NNC0165-1875 in Combination With Semaglutide Works in People With Obesity | Obesity | Phase 2 | Completed | 120 |
| NCT04998136 | Research Study Investigating How Well Semaglutide Works in People From Thailand and South Korea Living With Obesity | Obesity | Phase 3 | Completed | 150 |
| NCT05303857 | Analyse the Effect of Semaglutide on Vascular Structure and Function in Patients With Early Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 4 | Completed | 107 |
| NCT04016974 | A Research Study of How Oral Semaglutide Tablets Work in Healthy People Who Are Chinese | Healthy Volunteers, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 32 |
| NCT06215196 | Effectiveness and Safety of Semaglutide Combined With Dietary Fiber (Soloways) in Adults With Overweight or Obesity | Overweight and Obesity | Not phased | Completed | 81 |
| NCT06497049 | Open Randomized Study of Comparative Pharmacokinetics and Biosimilarity of GP40221 (GEROPHARM LLC, Russia) and Ozempic®. | Pharmacokinetics, Safety Issues | Phase 1 | Completed | 120 |
| NCT02305381 | Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to Basal Insulin Alone or Basal Insulin in Combination With Metformin in Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 397 |
| NCT05813249 | Semaglutide in Nonalcoholic Fatty Liver Disease | Non-alcoholic Fatty Liver Disease | Phase 4 | Completed | 180 |
| NCT06363487 | Semaglutide and Cognition in Healthy Volunteers | Cognitive Change | Not phased | Completed | 70 |
| NCT05530577 | Effects of Semaglutide on Nicotine Intake | Tobacco Use Disorder, Nicotine Addiction | Phase 2 | Completed | 24 |
| NCT06716307 | A Research Study to Compare Blood Levels of Cagrilintide and Semaglutide After Single Doses of Different Versions of Injectable CagriSema in Adults With Overweight or Obesity | Obesity | Phase 1 | Completed | 18 |
| NCT06323161 | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Once-daily Basal Insulin With or Without Metformin | Type 2 Diabetes | Phase 3 | Completed | 274 |
| NCT05877547 | A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013) | Non-alcoholic Fatty Liver Disease, Fatty Liver, Nonalcoholic | Phase 2 | Completed | 381 |
| NCT06388187 | A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose Weight | Obesity | Phase 3 | Completed | 300 |
| NCT04187300 | A Research Study Looking at the Comparability (Bioequivalence) of Two Forms of Semaglutide in Two Different Pen-injectors in People With Overweight or Obesity | Overweight, Obesity | Phase 1 | Completed | 68 |
| NCT06533527 | Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy | Diabetes Mellitus, Type 2, Obesity | Phase 4 | Completed | 69 |
| NCT02172313 | Effect of Food on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects | Diabetes, Healthy | Phase 1 | Completed | 78 |
| NCT07610174 | Effects of Dapagliflozin, Semaglutide, and Their Combination in Heart Failure Patients With Prosthetic Heart Valves | Heart Failure, Heart Valve Prosthesis | Phase 2 | Completed | 160 |
| NCT05670379 | Assessment of Safety, Tolerability and Drug Levels of Exenatide Implant | Overweight and Obesity, Type2diabetes | Phase 1 | Completed | 24 |
| NCT02773381 | A Trial Investigating the Effect of Oral Semaglutide Compared With Placebo on Postprandial Glucose and Triglyceride Metabolism, Energy Intake, Appetite Sensations and Gastric Emptying in Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 15 |
| NCT01324505 | Effect of Oral Contraceptives After Administration of Semaglutide in Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 43 |
| NCT05429593 | A Research Study Investigating How Semaglutide and Dapagliflozin Act in Your Body When Dosed in One Tablet | Healthy Volunteers | Phase 1 | Completed | 152 |
| NCT03136484 | Efficacy and Safety of Semaglutide Versus Canagliflozin as add-on to Metformin in Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 788 |
| NCT05035082 | A Research Study Comparing RYBELSUS® to Other Blood Sugar Lowering Tablets in People Living in America With Type 2 Diabetes (REALYSE) | Diabetes Mellitus, Type 2 | Phase 4 | Completed | 1020 |
| NCT04017832 | A Research Study Comparing a New Medicine Oral Semaglutide to Sitagliptin in People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 1441 |
| NCT02070510 | A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Lisinopril and Warfarin in Healthy Subjects | Diabetes, Healthy | Phase 1 | Completed | 52 |
| NCT03789578 | A Research Study to Look at How Insulin 287 and Semaglutide Work in the Body of People With Type 2 Diabetes When Taken Alone or Together | Diabetes Mellitus, Type 2 | Phase 1 | Completed | 30 |
| NCT03596450 | Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic Trial | Diabetes Mellitus, Type 2 | Phase 4 | Completed | 1278 |
| NCT05813925 | A Research Study to See How Well CagriSema Helps People in East Asia With Excess Body Weight Lose Weight | Obesity or Overweight | Phase 3 | Completed | 331 |
| NCT04238962 | A Research Study to Compare Two Different Forms of Once-weekly Semaglutide in Two Different Injection Pens | Overweight, Obesity | Phase 1 | Completed | 111 |
| NCT05891496 | A Research Study Looking at the Effect of Semaglutide on the Immune System and Other Biological Processes in People With Alzheimer's Disease | Alzheimers Disease | Phase 3 | Completed | 23 |
| NCT04074161 | Research Study to Investigate How Well Semaglutide Works Compared to Liraglutide in People Living With Overweight or Obesity | Overweight, Obesity | Phase 3 | Completed | 338 |
| NCT03638778 | Research Study Comparing Different Tablets With the Study Medicine Semaglutide in Healthy Men | Diabetes Mellitus, Type 2 | Phase 1 | Completed | 105 |
| NCT01720446 | Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 3297 |
| NCT05236517 | A Research Study Looking at How 50 mg Semaglutide Daily Affects Food Intake and Emptying of the Stomach in People With Obesity | Obesity | Phase 1 | Completed | 60 |
| NCT05514535 | A Research Study to Look Into How Semaglutide, Together With a Lower Dose of Insulin Glargine, Compares to a Higher Dose of Insulin Glargine Alone in People With Type 2 Diabetes (SUSTAIN OPTIMIZE) | Diabetes Mellitus, Type 2, Obesity | Phase 3 | Completed | 573 |
| NCT06184568 | A Study Comparing IBI362 vs Semaglutide in Chinese Adults With Early Type 2 Diabetes and Obesity | Type 2 Diabetes, Obesity | Phase 3 | Completed | 349 |
| NCT06492330 | Efficacy and Safety of CS0159 Combined With Semaglutide in MASH Patients With Obesity and T2DM | Metabolic Dysfunction-Associated Steatohepatitis (MASH), Obesity | Not phased | Completed | 62 |
| NCT06323174 | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Diet and Exercise | Type 2 Diabetes | Phase 3 | Completed | 189 |
| NCT03707990 | A Research Study of NNC0165-1875 Alone or Together With Semaglutide in People Who Are Overweight or Obese | Obesity and Overweight | Phase 1 | Completed | 88 |
| NCT03914326 | A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 9651 |
| NCT06131437 | A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight | Obesity | Phase 3 | Completed | 809 |
| NCT05533632 | Safety Study of Weekly Semaglutide in Chilean Participants With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 4 | Completed | 104 |
| NCT04538352 | Transition From Basal/Bolus to Once-weekly Subcutaneous Semaglutide and Basal Insulin in Patients With T2D | Type 2 Diabetes | Phase 4 | Completed | 60 |
| NCT02212067 | A Trial Investigating the Effects of Semaglutide on ß-cell Function in Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 87 |
| NCT04777409 | A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus) | Early Alzheimer´s Disease | Phase 3 | Completed | 1840 |
| NCT05822830 | A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities | Obesity, Overweight | Phase 3 | Completed | 751 |
| NCT05040971 | Research Study Looking at How Well Semaglutide Works in People Living With Obesity and Prediabetes | Obesity | Phase 3 | Completed | 207 |
| NCT01885208 | Efficacy and Safety of Semaglutide Once-weekly Versus Exenatide ER 2.0 mg Once-weekly as add-on to 1-2 Oral Antidiabetic Drugs (OADs) in Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 813 |
| NCT04102189 | A Research Study on How Well Semaglutide Works in Adolescents With Overweight or Obesity | Overweight, Obesity | Phase 3 | Completed | 201 |
| NCT05813912 | A Research Study to See How a New Weekly Insulin, Insulin Icodec When Given Along With Semaglutide Helps in Reducing the Blood Sugar Level in Patients With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 148 |
| NCT05205928 | Weekly Subcutaneous Semaglutide as Adjunct to Closed-loop Therapy in Type 1 Diabetes Care | Type 1 Diabetes, Diabetes Mellitus, Type 1 | Phase 3 | Completed | 28 |
| NCT05064735 | Research Study Looking at How Well Semaglutide Works in People Suffering From Obesity and Knee Osteoarthritis | Obesity | Phase 3 | Completed | 407 |
| NCT03086330 | Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to SGLT-2i in Subjects With Type 2 Diabetes Mellitus | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 302 |
| NCT04513704 | A Clinical Trial Comparing Semaglutide in Healthy People Who Eat and Take the Medicine at Different Times | Healthy Volunteers Type 2 Diabetes | Phase 1 | Completed | 156 |
| NCT02022254 | Influence of Semaglutide on Pharmacokinetics and Pharmacodynamics of Warfarin and Pharmacokinetics of Metformin in Healthy Subjects | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 24 |
| NCT00851773 | Safety, Tolerability, and Profile of Action of Drug in the Body of NN9535 in Healthy Male Japanese and Caucasian Subjects | Diabetes, Healthy | Phase 1 | Completed | 84 |
| NCT04189848 | Comparison of Injection Site Pain Experience for Semaglutide and Dulaglutide sc | Healthy Volunteers, Diabetes Mellitus, Type 2 | Phase 4 | Completed | 104 |
| NCT05132088 | Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in East Asian People Who Are Overweight or Living With Obesity | Overweight and Obesity | Phase 3 | Completed | 201 |
| NCT03191396 | Research Study Comparing a New Medicine Semaglutide to Liraglutide in People With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 577 |
| NCT05153564 | A Research Study Looking Into the Effect of Semaglutide and NNC0480 0389 on Blood Levels of a Birth Control Pill in Woman After Menopause | Diabetes Mellitus, Type 2 | Phase 1 | Completed | 27 |
| NCT06699329 | A Study of Enlicitide Decanoate (MK-0616) and Semaglutide in Healthy Adult Participants (MK-0616-023) | Healthy | Phase 1 | Completed | 38 |
| NCT03919929 | Treating PCOS With Semaglutide vs Active Lifestyle Intervention | PCOS, Adolescent Obesity | Phase 3 | Completed | 60 |
| NCT06640972 | Effects of RDX-002 on Postprandial Triglycerides in Patients Discontinuing GLP-1 Agonists | Triglycerides, Weight Gain Trajectory | Phase 2 | Completed | 68 |
| NCT00813020 | A Clinical Trial Investigating the Comparison of Three Different Concentrations of NN9535 in Healthy Male Subjects | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 44 |
| NCT02079870 | Trial Investigating the Effect of Semaglutide on Energy Intake, Appetite Sensations, Postprandial Glucose and Triglyceride Metabolism and Gastric Emptying in Obese Subjects Compared With Placebo | Diabetes, Metabolism and Nutrition Disorder | Phase 1 | Completed | 30 |
| NCT05352815 | A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Weekly Insulin Icodec | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 1291 |
| NCT06269107 | A Research Study to See How Well New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Levels in People With Type 2 Diabetes (T2D), Compared to Daily Insulin Glargine (COMBINE 4) | Type 2 Diabetes | Phase 3 | Completed | 485 |
| NCT03466567 | A Trial Investigating the Effect of Probenecid and Ciclosporin on the Concentrations of SNAC in Healthy Subjects | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 21 |
| NCT04817644 | A Research Study to See How Much Semaglutide and SNAC is in the Milk of Healthy, Breastfeeding Women Taking Semaglutide Tablets | Diabetes Mellitus, Type 2 | Phase 1 | Completed | 14 |
| NCT06161844 | Efficacy and Safety of Semaglutide Injection (HD1916) in Patients With Type 2 Diabetes Mellitus | Type 2 Diabetes Mellitus | Phase 3 | Completed | 506 |
| NCT02607865 | Efficacy and Long-term Safety of Oral Semaglutide Versus Sitagliptin in Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 1864 |
| NCT04007107 | A Study Comparing the Injection Site Pain Experience After the Injection of 2 Different Solutions of Semaglutide With 2 Different Injection Pens, a Compound for the Treatment of Type 2 Diabetes and Obesity | Healthy Volunteers Diabetes Mellitus, Type 2, Healthy Volunteers Overweight | Phase 2 | Completed | 103 |
| NCT06045221 | A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin | Type 2 Diabetes | Phase 3 | Completed | 1698 |
| NCT05892432 | Clinical Trial of Rybelsus (Semaglutide) Among Adults With Alcohol Use Disorder (AUD) | Alcohol Use Disorder | Phase 2 | Completed | 50 |
| NCT03552757 | Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity | Obesity, Overweight | Phase 3 | Completed | 1210 |
| NCT02827708 | Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes and Moderate Renal Impairment | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 324 |
| NCT06771115 | Phase 2a Placebo-Controlled Study of VTX3232 Alone or in Combination With Semaglutide in Obesity | Obesity | Phase 2 | Completed | 176 |
| NCT06604624 | Semaglutide in Treatment of Obesity | Weight Management | Phase 3 | Completed | 462 |
| NCT03600480 | A Research Study of How NNC0174-0833 Taken With Semaglutide Works in People Who Are Overweight or Obese | Obesity, Overweight | Phase 1 | Completed | 96 |
| NCT04971785 | Study of Semaglutide, and Cilofexor/Firsocostat, Alone and in Combination, in Adults With Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) | Nonalcoholic Steatohepatitis | Phase 2 | Completed | 457 |
| NCT02461589 | Dose-finding of Semaglutide Administered Subcutaneously Once Daily Versus Placebo and Liraglutide in Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 2 | Completed | 706 |
| NCT05302596 | Semaglutide Use in Elderly Obese Patients | Obesity, Aging | Phase 2 | Completed | 16 |
| NCT02146079 | A Trial to Assess the Pharmacokinetics, Pharmacodynamics, and the Safety and Tolerability of Semaglutide in Healthy Male Japanese and Caucasian Subjects | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 44 |
| NCT06534411 | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 1023 |
| NCT02207374 | A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly in Monotherapy or in Combination With One OAD in Japanese Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 601 |
| NCT06500429 | A Study to Evaluate the Safety and Efficacy of NG101 in Adult Participants Receiving a Glucagon-like Peptide-1 (GLP-1) Agonist | Overweight and Obesity, Healthy | Phase 2 | Completed | 120 |
| NCT02692716 | A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 3183 |
| NCT06097390 | A Research Study Looking at New Protein-based Tablets in Healthy Men - Oral Formulation III | Healthy Participants | Phase 1 | Completed | 121 |
| NCT02014259 | Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Various Degrees of Impaired Renal Function | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 71 |
| NCT02060266 | Trial Investigating the Absorption, Metabolism and Excretion After a Single Subcutaneous Dose of [3H]-Semaglutide in Healthy Male Subjects | Diabetes, Healthy | Phase 1 | Completed | 7 |
| NCT04865770 | A Research Study to Find Out How Semaglutide Works in the Kidneys Compared to Placebo, in People With Type 2 Diabetes and Chronic Kidney Disease (the REMODEL Trial) | Diabetes Mellitus, Type 2, Chronic Kidney Disease | Phase 3 | Completed | 106 |
| NCT07163624 | UBT251 Injection Phase II (Type 2 Diabetes Mellitus) Study | Type 2 Diabetes Mellitus (T2DM) | Phase 2 | Completed | 211 |
| NCT06605703 | A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepatide (GLP1 Transition Trial) | Obesity, Overweight | Phase 4 | Completed | 226 |
| NCT05227196 | A Research Study Looking at the Comparability of 2 Different Forms of Oral Semaglutide in Healthy People | Healthy Volunteers, Type 2 Diabetes | Phase 1 | Completed | 546 |
| NCT01619345 | Pharmacoscintigraphic Investigation of NN9924 in Healthy Male Subjects | Diabetes, Healthy | Phase 1 | Completed | 27 |
| NCT04152915 | A Research Study Looking at Similarity Between Once-weekly Semaglutide Versions for Different Injection Pens | Healthy Volunteers, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 68 |
| NCT04109508 | A Research Study Comparing Active Drug in the Blood in Healthy Participants Following Dosing of the Current and a New Formulation (C) Semaglutide Tablets | Healthy Volunteers, Type 2 Diabetes | Phase 1 | Completed | 278 |
| NCT02054897 | Efficacy and Safety of Semaglutide Once-weekly Versus Placebo in Drug-naïve Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 388 |
| NCT03611322 | A Trial to Compare Blood Concentration Levels of Semaglutide Following Subcutaneous Injections of Semaglutide 1 mg by 2 Different Devices (the DV3372 Device and by the PDS290 Semaglutide Pen-injector) | Diabetes Mellitus, Type 2 | Phase 1 | Completed | 54 |
| NCT05646706 | A Research Study to See How Semaglutide Helps People With Excess Weight, Lose Weight (STEP UP) | Obesity | Phase 3 | Completed | 1407 |
| NCT02254291 | A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly Versus Sitagliptin Once Daily in Japanese Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | 308 |
| NCT03987451 | A Research Study on How Semaglutide Works in People With Fatty Liver Disease and Liver Damage | Non-alcoholic Steatohepatitis | Phase 2 | Completed | 71 |
| NCT05390307 | Obesity Treatment to Improve Diabetes | Type 1 Diabetes | Not phased | Completed | 60 |
| NCT04263415 | The Effects of Semaglutide on Taste, Tongue Tissue Transcriptome, Gastric Emptying and Central Neural Response in Women With PCOS and Obesity | PCOS, Semaglutide | Phase 4 | Completed | 30 |
| NCT05816057 | A Study of the Efficacy and Safety of Semaglutide Injection in the Treatment of Type 2 Diabetes Mellitus | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 476 |
| NCT06065540 | A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor | Type 2 Diabetes Mellitus | Phase 3 | Completed | 2734 |
| NCT01272973 | Investigation on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NN9924 in Healthy Male Subjects | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 96 |
| NCT03357380 | A Study on How Semaglutide Works on Early Stages of Scar Tissue in the Liver Assessed by Pictures of the Liver | Hepatobiliary Disorders, Non-alcoholic Fatty Liver Disease | Phase 1 | Completed | 67 |
| NCT07280403 | Effect of a Low-carbohydrate Diet on Weight Loss in People Using the Injectable GLP-1 Agonist Semaglutide for Weight Loss | Weight Loss | Not phased | Completed | 60 |
| NCT04779697 | GLP-1 Analogue Effects on Food Cues, Stress, Motivation for Highly Palatable Foods, and Weight | Obesity | Phase 1 | Completed | 96 |
| NCT06207877 | A Research Study to Look at How CagriSema Influences Food Intake, Appetite and Emptying of the Stomach in People With Excess Body Weight | Obesity | Phase 1 | Completed | 62 |
| NCT04466345 | Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive Disorder | Major Depressive Disorder | Phase 2 | Completed | 72 |
| NCT07368855 | GLP-1 Medicines and Mental Health Changes | Obesity, Depression | Not phased | Completed | 90 |
| NCT05574439 | Young Adults With Early-onset Obesity Treated With Semaglutide | Obesity, Adolescent | Phase 4 | Completed | 246 |
| NCT04524832 | Research Study Comparing New Tablets of Semaglutide in New Doses, in Healthy People | Diabetes Mellitus, Type 2 | Phase 1 | Completed | 290 |
| NCT04515849 | A Study of Cotadutide in Participants Who Have Chronic Kidney Disease With Type 2 Diabetes Mellitus | Type 2 Diabetes Mellitus, Chronic Kidney Diseases | Phase 2 | Completed | 248 |
| NCT04596631 | A Research Study to Compare a New Medicine Oral Semaglutide to a Dummy Medicine in Children and Teenagers With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 132 |
| NCT01866748 | Investigation on Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses of a Long-acting GLP-1 Analogue (Semaglutide) in an Oral Formulation in Healthy Male Subjects | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 170 |
| NCT05015894 | A Research Study Looking Into Blood Levels of the Medicine NNC0480-0389 in Participants With Reduced Kidney Function Compared to Participants With Normal Kidney Function | Diabetes Mellitus, Type 2 | Phase 1 | Completed | 42 |
| NCT02557620 | Comparing Semaglutide Administered Subcutaneously Once Daily to Semaglutide Administered Subcutaneously Once Weekly | Diabetes, Healthy | Phase 1 | Completed | 113 |
| NCT04032197 | A Research Study of How Semaglutide Works in People With Disease Affecting the Heart and/or Blood Vessels and Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 1 | Completed | 101 |
| NCT06634927 | Pharmacokinetic Similarity, Safety, and Immunogenicity of Semaglutide Injection and Ozempic ® Injection in Healthy Subjects. | Type 2 Diabetes | Phase 1 | Completed | 68 |
| NCT02920385 | A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Levothyroxine and the Influence of Co-administered Tablets on the Pharmacokinetics of Semaglutide Administered Orally in Healthy Subjects. | Diabetes, Healthy | Phase 1 | Completed | 45 |
| NCT03144271 | Dose Escalation Trial of Single Subcutaneous Doses of NNC 0113-0217 to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Male Subjects | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 58 |
| NCT06267092 | A Study of How CagriSema Works on Appetite in People With Excess Body Weight | Overweight, Obesity | Phase 1 | Completed | 164 |
| NCT06972992 | A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC47 in Combination With Semaglutide | Chronic Weight Management | Phase 1 | Completed | 28 |
| NCT05498610 | A Research Study of How the Medicine NNC0480-0389 Taken With Semaglutide Works in the Body of Healthy Chinese Men | Diabetes Mellitus, Type 2 | Phase 1 | Completed | 24 |
| NCT02161588 | A Trial to Assess the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Oral Semaglutide in Healthy Male Japanese and Caucasian Subjects | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 48 |
| NCT06221696 | Preventing Weight Regain Post-Semaglutide Treatment With Active Fiber Supplement (Soloways) | Overweight and Obesity | Not phased | Completed | 160 |
| NCT05786521 | Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults | Aging, Diabetes Mellitus, Type 2 | Phase 4 | Completed | 20 |
| NCT06041217 | A Research Study to See How Well Semaglutide Helps People Who Have a Body Weight Above the Healthy Weight Range | Overweight, Obesity | Phase 3 | Completed | 242 |
| NCT07096739 | Tolerance of a High Protein Nutrition Shake in Individuals on GLP-1 | GLP-1 Concentration | Not phased | Completed | 20 |
| NCT01686945 | Investigation on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of a Long-acting GLP-1 Analogue in Healthy Male Subjects and Male Subjects With Type 2 Diabetes | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 107 |
| NCT04788511 | Research Study to Investigate How Well Semaglutide Works in People Living With Heart Failure and Obesity | Obesity | Phase 3 | Completed | 529 |
| NCT03598621 | A Research Study to Look at Similarity Between Semaglutide Versions in Different Injection Tools | Diabetes Mellitus, Type 2 | Phase 1 | Completed | 68 |
| NCT06974825 | A Study of BGM0504 in Chinese Patients With Type 2 Diabetes | Type 2 Diabetes | Phase 2 | Completed | 67 |
| NCT05435677 | A Research Study to Look at How Insulin Icodec and Semaglutide Work in the Body of People From China With Type 2 Diabetes When Given Alone or Together | Diabetes Mellitus, Type 2 | Phase 1 | Completed | 20 |
| NCT02231684 | Investigating the Pharmacokinetics of Subcutaneous Injections With 1 mg/mL, 3 mg/mL, and 10 mg/mL Semaglutide Strengths and the Absolute Bioavailability of Semaglutide | Diabetes, Healthy | Phase 1 | Completed | 42 |
| NCT06489457 | The Effects of Semaglutide vs Testosterone Replacement Therapy on Functional Hypogonadism and Sperm Quality in Men With Type 2 Diabetes Mellitus and Obesity | Type 2 Diabetes Mellitus, Obesity | Phase 3 | Completed | 25 |
| NCT06292065 | Gastric Ultrasound To Assess Gastric Contents In Patients On Semaglutide Therapy | Gastroparesis | Not phased | Completed | 88 |
| NCT03724981 | A Study Comparing the Dulaglutide Pen and the Semaglutide Pen | Diabetes Mellitus, Type 2 | Phase 4 | Completed | 312 |
| NCT04979130 | Comparing Semaglutide Versus Placebo on Intestinal Barrier Function in Type 2 Diabetes Mellitus (SIB) | Type 2 Diabetes, Chronic Inflammation | Phase 4 | Completed | 69 |
| NCT02249910 | Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Metformin and Digoxin in Healthy Subjects | Diabetes, Healthy | Phase 1 | Completed | 32 |
| NCT05016882 | Research Study on Whether a Combination of 2 Medicines (NNC0194 0499 and Semaglutide) Works in People With Non-alcoholic Steatohepatitis (NASH) | Non-alcoholic Steatohepatitis | Phase 2 | Completed | 698 |
| NCT02016911 | Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Hepatic Impairment | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 56 |
| NCT03574584 | A Research Study of NNC0165-1562 and Semaglutide in People Who Are Overweight or Obese | Metabolism and Nutrition Disorders, Overweight or Obesity | Phase 1 | Completed | 37 |
| NCT06069895 | Investigation of Safety, Tolerability and Pharmacokinetics of Multiple Doses of NNC0113-6856 in Healthy Participants, Including a Subset of Healthy Japanese Participants | Healthy Participants | Phase 1 | Completed | 170 |
| NCT01572753 | Investigation of Optimal Dosing Conditions for a Long Acting GLP-1 Analogue in Healthy Male Subjects | Diabetes, Diabetes Mellitus, Type 2 | Phase 1 | Completed | 161 |
| NCT06403761 | Investigating How CagriSema, Semaglutide and Cagrilintide Regulate Insulin Effects in the Body of People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 1 | Completed | 158 |
| NCT05996874 | A Research Study Comparing the Effect of Different Dosing Conditions on Blood Levels of Semaglutide in a New Tablet Composition in Healthy Participants | Healthy Participants | Phase 1 | Completed | 121 |
| NCT05751226 | A Study in People With Overweight or Obesity to Test How Well Different Doses of BI 1820237 Are Tolerated When Given Alone or in Combination With Either Semaglutide or BI 456906 | Healthy, Obesity | Phase 1 | Completed | 88 |
| NCT03819153 | A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 3533 |
| NCT04109547 | A Research Study Comparing a New Medicine Oral Semaglutide to Placebo in People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Completed | 521 |
| NCT03611582 | Research Study to Look at How Well Semaglutide is at Lowering Weight When Taken Together With an Intensive Lifestyle Program | Overweight, Obesity | Phase 3 | Completed | 611 |
| NCT05232708 | A Clinical Trial Looking at the Comparability of 2 Different Forms of Semaglutide | Healthy Volunteers (Diabetes Mellitus, Type 2) | Phase 1 | Completed | 18 |
| NCT07220629 | Study to Explore the Safety and Efficacy of NT-0796 as an Adjunct to Semaglutide in Participants With Obesity (RESOLVE-2) | Obesity | Phase 2 | Running, closed to new participants | 82 |
| NCT04741074 | Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy | CKD, Diabetic Kidney Disease | Phase 3 | Stopped early | 15 |
| NCT06851962 | Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes. | Diabetes Mellitus Type 2 | Phase 4 | Running, closed to new participants | 504 |
| NCT04383197 | Exercise and GLP-1 RA on Insulin Secretion | Type 2 Diabetes | Not phased | Status not updated | 30 |
| NCT05597202 | Does the Hematopoietic Stem Cell Govern Residual Inflammatory Cardiovascular Risk in Type 2 Diabetes | Type 2 Diabetes | Phase 4 | Status not updated | 22 |
| NCT06577090 | Study to Evaluate the Effect on Obesity of QW Nimacimab and QW Nimacimab Co-administered With Semaglutide vs Placebo | Obesity | Phase 2 | Running, closed to new participants | 136 |
| NCT03811561 | A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Running, closed to new participants | 1500 |
| NCT05990374 | Therapeutic Effects and Effects on Body Fat of GLP-1 Receptor Agonists in Patients With Type 2 Diabetes for 1-4 Years | Diabetes | Not phased | Status not updated | 100 |
| NCT06754163 | Evaluating the Effect of the STEP@STAH Semaglutide Protocol on the Physical Health Measures of Atypical Antipsychotic-Treated Patients | Obesity and Obesity-related Medical Conditions, Psychiatric Disorders | Phase 4 | Running, closed to new participants | 20 |
| NCT06797869 | A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy | Diabetes Mellitus, Type 2, Diabetic Peripheral Neuropathy | Phase 2 | Running, closed to new participants | 142 |
| NCT06801015 | Effects of Long-Acting GLP-1 (Glucagon-like Peptide-1) or Dual Incretin (GLP-1 and GIP [Glucose-dependent Insulinotropic Peptide]) Modulation on Gastric Motor Functions | Obesity | Phase 4 | Running, closed to new participants | 30 |
| NCT05950516 | Efficacy and Safety of Semaglutide Ingection in Subjects With Type 2 Diabetes | Type 2 Diabetes | Phase 3 | Status not updated | 478 |
| NCT06299098 | A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation | Obesity | Phase 2 | Running, closed to new participants | 1005 |
| NCT05579977 | Trial to Learn About the Study Medicine (PF-07081532) and Rybelsus in People With Type 2 Diabetes and Separately PF-07081532 in People With Obesity | Diabetes Mellitus, Obesity | Phase 2 | Stopped early | 902 |
| NCT04854083 | Semaglutide as an Adjunct to Dieting in the Treatment of Type 2 Diabetes | Type2 Diabetes | Phase 4 | Status not updated | 50 |
| NCT05671653 | A Study to Evaluate the Effect of the Experimental GLP-1 Drug PF-07081532 on Blood Levels of Common Birth Control Pills, and Drugs Omeprazole and Midazolam, and Effect of GLP-1 Drug Semaglutide on Midazolam Blood Levels in Healthy Adults With Weight in the Obesity Range | Obesity | Phase 1 | Stopped early | 32 |
| NCT05195944 | Semaglutide vs Sitagliptin | Liver Transplant; Complications, Diabetes Mellitus | Phase 4 | ENROLLING_BY_INVITATION | 58 |
| NCT05254314 | Glucagon-Like Peptide-1 Receptor Agonist in the Treatment of Adult, Obesity-related, Symptomatic Asthma (GATA-3) | Asthma | Phase 2 | Running, closed to new participants | 100 |
| NCT06243536 | The Effect of Semaglutide on Disordered Eating Behaviour in Type 2 Diabetic Patients | Type 2 Diabetes, Overweight | Phase 4 | Status not updated | 60 |
| NCT07172867 | A Ph2 Study to Evaluate the Safety, Efficacy and Tolerability of HT-6184 and Semaglutide in Obese Participants With T2DM | Diabetes Mellitus, Type 2, Obesity | Phase 2 | Withdrawn before enrolling | 0 — nobody enrolled |
| NCT07357740 | A Research Study to Compare Two Different Versions of Injectable CagriSema in People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 2 | Withdrawn before enrolling | 0 — nobody enrolled |
| NCT07285902 | A Study Comparing the Efficacy and Safety of HRS9531 Injection With Semaglutide Injection in Subjects With Obesity | Obesity | Phase 3 | Running, closed to new participants | 572 |
| NCT05702905 | Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome | PCOS (Polycystic Ovary Syndrome), Semaglutide | Phase 4 | Status not updated | 75 |
| NCT06884293 | A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease （MAFLD） | Overweight, Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) | Phase 3 | Running, closed to new participants | 479 |
| NCT06361823 | Exploratory Study on the Efficacy and Safety of Semaglutide for Idiopathic Intracranial Hypertension Treatment | Idiopathic Intracranial Hypertension | Phase 3 | Status not updated | 74 |
| NCT06363747 | The Medically Reproducing Bariatric Surgery (MRB) II Study | Type 2 Diabetes, Obesity | Phase 3 | Running, closed to new participants | 50 |
| NCT05444153 | Research Study to Compare Semaglutide Tablets With Empagliflozin Tablets Taken Once Daily in People With Type 2 Diabetes and Obesity | Diabetes Mellitus, Type 2 | Phase 3 | Withdrawn before enrolling | 0 — nobody enrolled |
| NCT07011667 | A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term | Obesity | Phase 3 | Running, closed to new participants | 609 |
| NCT07677995 | Free Fatty Acid Effects In Type 2 Diabetes | Type 2 Diabetes, Cardiovascular Disease | Not phased | ENROLLING_BY_INVITATION | 60 |
| NCT06780449 | A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity | Obesity | Phase 3 | Running, closed to new participants | 400 |
| NCT04019197 | Effects of Semaglutide in HIV-Associated Lipohypertrophy | HIV/AIDS, Lipohypertrophy | Phase 2 | Running, closed to new participants | 108 |
| NCT05073835 | Semaglutide 2.4 mg in Patients With Poor Weight-loss | Obesity, Diabetes | Phase 3 | Running, closed to new participants | 70 |
| NCT05371496 | Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction | Cardiomyopathy, Heart Failure With Preserved Ejection Fraction (HFpEF) | Phase 4 | ENROLLING_BY_INVITATION | 81 |
| NCT05333003 | Semaglutide in Comorbid Schizophrenia Spectrum Disorder and Obesity | Schizophrenia Spectrum Disorders | Not phased | Running, closed to new participants | 92 |
| NCT05606471 | Glucagon-like Peptide-1 Agonism With Very Low Calorie Diets | Type 2 Diabetes Mellitus in Obese | Phase 4 | Status not updated | 45 |
| NCT07073417 | A Study to Compare XW003 Injection and Semaglutide Injection in Chinese Adults With Obesity (SLIMMER-UP-SWITCH) | Obesity, Weight Management | Phase 2 | Running, closed to new participants | 163 |
| NCT05071417 | Effect Of Semaglutide In Coronary Atheroma Plaque | Atheroscleroses, Coronary | Phase 3 | Status not updated | 120 |
| NCT05870462 | Semaglutide and Vascular Regeneration | Atherosclerosis, Cardiovascular Diseases | Phase 4 | Status not updated | 100 |
| NCT05249881 | "Efficacy of Once Weekly GLP 1 Analogue: Semaglutide. A Multicenter Experience From Pakistan." | Diabetes Mellitus, Type 2, Weight Change, Body | Phase 1 | Status not updated | 300 |
| NCT06982859 | A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellitus | Diabetes Mellitus, Insulin Sensitivity | Phase 1 | Running, closed to new participants | 95 |
| NCT06344247 | Comparison of the Efficacy and Safety of SGLT2i and GLP-1 Receptor Agonists in Obese Patients With Kidney Disease | Obesity, Chronic Kidney Diseases | Not phased | Status not updated | 48 |
| NCT06050577 | The Effect of Oral Semaglutide on Bone Turnover in Patients With T2D: a Randomized Placebo-controlled Clinical Trial | Type 2 Diabetes, Osteopenia | Phase 2 | Running, closed to new participants | 64 |
| NCT05196958 | Interest of GLP1 Analogues in Overweight Type 2 Diabetic Patients With Chronic Inflammatory Bowel Disease | Inflammatory Bowel Diseases, Diabetes Mellitus, Type 2 | Not phased | Status not updated | 20 |
| NCT06222437 | Semaglutide and Polycystic Ovarian Syndrome: an Emerging Treatment Strategy | Polycystic Ovary Syndrome | Phase 1 | Withdrawn before enrolling | 0 — nobody enrolled |
| NCT05442450 | Efficacy of Oral Semaglutide in Overweight or Obesity | Obesity, Weight Loss | Phase 4 | Status not updated | 116 |
| NCT06149260 | Subcutaneous Semaglutide in Systemic Scleroderma | Scleroderma, Systemic, Fibrosis | Phase 1 | Status not updated | 10 |
| NCT06422624 | A Study to Evaluate Safety, Tolerability and pK of Semaglutide ER Injectable Suspension in Healthy, Adult Human Subjects | Diabetes Mellitus, Type 2 | Phase 1 | Status not updated | 14 |
| NCT05147896 | Semaglutide Anti-Atherosclerotic Mechanisms of Action Study in Type 2 Diabetes Patients | Diabetes Mellitus, Type 2, Atherosclerosis | Not phased | Status not updated | 100 |
| NCT06655740 | Safety, Tolerability, and Effectiveness of Duodenal Mucosal RF Vapor Ablation for Insulin Elimination in Type-2 Diabetes | Diabetes Mellitus, Type 2 | Not phased | Running, closed to new participants | 16 |
| NCT04624672 | Treatment of GLP-1 for Diabetic Bariatric Patients | Diabetes Mellitus, Type 2 | Phase 4 | Stopped early | 3 |
| NCT04702516 | The Effect of Semaglutide on Bone Turnover in Patients With Increased Risk of Bone Fracture | Osteopenia | Phase 2 | Status not updated | 64 |
| NCT06571383 | STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss | Obesity | Phase 4 | Running, closed to new participants | 500 |
| NCT07505303 | MIST (Metabolic Intervention With Semaglutide and THR-β Therapy) Trial | Adult Obesity, Weight Management | Phase 2 | Running, closed to new participants | 151 |
| NCT04822181 | Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH) | Non-alcoholic Steatohepatitis | Phase 3 | Running, closed to new participants | 1205 |
| NCT04938388 | Comparison of Oral Semaglutide w/ Placebo- Treatment for Latino Adults w/T2 Diabetes Receiving Enhanced Lifestyle Care | Diabetes Mellitus, Type 2, Glucose Metabolism Disorders (Including Diabetes Mellitus) | Phase 4 | Stopped early | 12 |
| NCT04447859 | 16-week Flexible vs. 8-week Semaglutide Titration | Diabetes type2 | Phase 3 | Status not updated | 100 |
| NCT06260722 | Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2) | Diabetes Mellitus, Type 2 | Phase 3 | Running, closed to new participants | 1250 |
| NCT06803888 | Bariatric Surgery vs. Semaglutide vs. Tirzepatide | Obesity and Obesity-related Medical Conditions | Phase 4 | Running, closed to new participants | 125 |
| NCT06426446 | Monitoring Patients With Severe Obesity Treated With Wegovy® Using Connected Device: Real-world Data | Obesity | Not phased | Status not updated | 80 |
| NCT04012255 | A Research Study to Compare Two Forms of Semaglutide in Two Different Pen-injectors in People With Overweight or Obesity | Overweight, Obesity | Phase 1 | Stopped early | 29 |
| NCT05829460 | Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Endometrial Hyperplasia | Endometrial Hyperplasia | Phase 2 | Withdrawn before enrolling | 0 — nobody enrolled |
| NCT05202353 | A Study in People With Obesity to Test the Effects of BI 456906 Compared With Semaglutide on Glucagon Receptor Activity in the Liver | Obesity | Phase 1 | Running, closed to new participants | 29 |
| NCT04615871 | Semaglutide to Reduce Myocardial Injury in PATIents With COVID-19 | Covid19, Myocardial Injury | Phase 2 | Status not updated | 400 |
| NCT06745284 | A Study to Test Whether Survodutide Improves How the Body Uses Energy and Breaks Down Fat in People With Obesity | Obesity | Phase 1 | Running, closed to new participants | 64 |
| NCT05616052 | Comparison of Body Weight Change Through Different Smeglutide Administration Methods | Weight Change, Body | Phase 4 | Status not updated | 80 |
| NCT07087795 | A Study to See the Effect of NNC0194-0499 Alone or in Combination With Semaglutide on Blood Sugar Control in People Living With Type 1 Diabetes | Diabetes Mellitus, Type 1 | Phase 1 | Running, closed to new participants | 96 |
| NCT06959784 | Assessing Incretin Therapy for Cardiovascular Risk Reduction and Diabetes Remission( ITCRDR Study) | Diabetes Mellitus, Cardiovascular Diseases | Phase 4 | ENROLLING_BY_INVITATION | 142 |
| NCT05567796 | A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight | Obesity | Phase 3 | Running, closed to new participants | 3400 |
| NCT06015893 | Semaglutide Therapy for Alcohol Reduction (STAR) | Addiction, Alcohol Use Disorder | Phase 2 | Running, closed to new participants | 63 |
| NCT06649344 | A Study of HRS9531 Versus Semaglutide Once Weekly as Add-on Therapy to Metformin Monotherapy or in Combination With SGLT2 Inhibitors in Participants With Type 2 Diabetes | Type 2 Diabetes | Phase 3 | Running, closed to new participants | 884 |
| NCT06057077 | Semaglutide GLP1 Agonists With Degludec Basal-bolus Insulin in Early Type 1 Diabetes to Basal-bolus | Type 1 Diabetes | Phase 2 | Status not updated | 120 |
| NCT06083675 | Research Study to Compare Semaglutide Tablets With Empagliflozin or Metformin Tablets in People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Withdrawn before enrolling | 0 — nobody enrolled |
| NCT06814938 | A Study of a Novel Precision Medicine Approach For Obesity | Obesity | Phase 4 | Running, closed to new participants | 135 |
| NCT05669755 | REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels | Cardiovascular Disease | Phase 3 | Running, closed to new participants | 7101 |
| NCT06005012 | Semaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM | Fibrosis, Liver, Type 2 Diabetes Mellitus in Obese | Phase 2 | Running, closed to new participants | 120 |
| NCT05441267 | A Study of Cardiovascular Events iN Diabetes Plus | Diabetes Mellitus, Type 2 | Phase 4 | Running, closed to new participants | 21296 |
| NCT06827002 | Effect of Aqueous Extracts of Cissus Quadrangularis and Dichrostachys Glomerata on GLP-1 Concentration and DPP-4 Activity in Overweight and Obese Adults | Obesity and Overweight, Appetite Regulation | Phase 2 | Running, closed to new participants | 248 |
| NCT04451837 | Semaglutide and Dapagliflozin in Diabetic Patients With Different Pathophysiology | Type2 Diabetes | Phase 2 | Running, closed to new participants | 200 |
| NCT06854614 | Sequential or CombinaTion Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial) | Obesity | Phase 4 | Running, closed to new participants | 150 |
| NCT05751720 | Effect on Non-Alcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus With Gastric Inhibitory Polypeptide/Glucagon Like Peptide-1 Analogue | Non-Alcoholic Fatty Liver Disease, Non-alcoholic Steatohepatitis | Phase 2 | Status not updated | 30 |
| NCT06778967 | A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus | Type 2 Diabetes Mellitus (T2DM) | Phase 3 | Running, closed to new participants | 1100 |
| NCT05812183 | Gastric Sleeve-Induced Weight Loss on Shortness of Breath in Obesity | Dyspnea, Quality of Life | Phase 4 | Withdrawn before enrolling | 0 — nobody enrolled |
| NCT03659682 | GLP1R in Parkinson's Disease | Parkinson Disease | Phase 2 | Status not updated | 120 |
| NCT07271251 | A Research Study to See if Two Different Formulations of Oral Semaglutide Are Equally Safe and Effective in Reducing the Blood Sugar Level in Japanese People With Type 2 Diabetes | Type 2 Diabetes | Phase 3 | Running, closed to new participants | 264 |
| NCT05897372 | Feasibility of Aggressive Albuminuria Reduction in Biopsy-Proven Diabetic Nephropathy - a Pilot Study | Diabetic Kidney Disease | Phase 2 | Stopped early | 1 |
| NCT07357766 | A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body Weight | Overweight, Obesity | Phase 3 | Withdrawn before enrolling | 0 — nobody enrolled |
| NCT06619015 | Tailoring Obesity Treatment Trial | Obesity, Appetite Regulation | Phase 3 | Withdrawn before enrolling | 0 — nobody enrolled |
| NCT04135287 | Relationship Between Improvement in Insulin Secretion and Decrease in HbA1c in GLP-1 RA Therapy in T2DM Patients | Diabetes Mellitus, Type 2 | Phase 4 | Status not updated | 315 |
| NCT04287179 | SUSTAIN SWITCH: A Research Study to Compare Two Dose Schedules of Semaglutide Taken Once Weekly in People With Type 2 Diabetes | Diabetes Mellitus, Type 2 | Phase 3 | Withdrawn before enrolling | 0 — nobody enrolled |
| NCT05209165 | Semaglutide to Reduce Atrial Fibrillation Burden | Atrial Fibrillation, Obesity | Phase 4 | Suspended | 132 |
| NCT07112872 | A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes | Type 2 Diabetes Mellitus | Phase 2 | Running, closed to new participants | 240 |
| NCT06339086 | Efficacy and Safety of Semaglutide Injection in Subjects With Type 2 Diabetes | Type 2 Diabetes Mellitus | Phase 3 | Status not updated | 478 |
| NCT07325435 | Beta Cell Function in Type 2 Diabetes: Differential Effects of SGLT2 Inhibitors and GLIP-Receptor Agonists | Type 2 Diabetes (T2DM) | Phase 4 | Running, closed to new participants | 60 |
| NCT05322200 | The POST-ACS Study | Diabetes Mellitus, Acute Coronary Syndrome | Phase 4 | Status not updated | 140 |
| NCT04061200 | Renal Effects of Treatment With Empagliflozin Alone or in Combination With Semaglutide in Patients With Type 2 Diabetes and Albuminuria | Type 2 Diabetes With Renal Manifestations | Phase 4 | Status not updated | 80 |
| NCT04885634 | Semaglutide for the Reduction of Arrhythmia Burden in Overweight AF Patients | Atrial Fibrillation, Overweight and Obesity | Phase 3 | Withdrawn before enrolling | 0 — nobody enrolled |
| NCT05646199 | Semaglutide vs Metformin in Polycystic Ovary Syndrome (PCOS) | Polycystic Ovary Syndrome | Phase 3 | Status not updated | 60 |
| NCT06256549 | A Study of GZR18 Injection in Chinese Patients With Type 2 Diabetes Mellitus | Type 2 Diabetes | Phase 2 | Status not updated | 272 |
| NCT05067621 | Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease | Type 2 Diabetes Mellitus, Impaired Glucose Tolerance | Phase 2 | Running, closed to new participants | 60 |
| NCT05040087 | Changing the Natural History of Type 2 Diabetes ("CHANGE" Study) | Type 2 Diabetes | Not phased | Running, closed to new participants | 127 |
| NCT04892199 | Does GLP-1RA Prevent Deterioration of Metabolic State in Prediabetic and Diabetic Patients Treated With Antipsychotic Medication? | Metabolic Disturbance, Schizophrenia | Phase 4 | Running, closed to new participants | 104 |
| NCT06954090 | Urinary Proteomics to Guide Early Intervention to Prevent Complications in Type 2 Diabetes - a Feasibility Study | Type 2 DM, Type 2 DM /Diabetic Nephropathy | Phase 4 | ENROLLING_BY_INVITATION | 50 |
| NCT07092605 | Effectiveness of Microdosed GLP-1 in Improving Health, Quality of Life, and Longevity Measures | Longevity, Quality of Life | Phase 1 | ENROLLING_BY_INVITATION | 150 |
| NCT05726227 | A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight | Obesity | Phase 3 | Running, closed to new participants | 210 |
| NCT06042153 | DIALYSIS-TIR Study | Type 2 Diabetes, End Stage Renal Disease on Dialysis | Phase 4 | Running, closed to new participants | 43 |
| NCT07478198 | Study on the Efficacy and Safety of PLLA Injections for Improving Facial Laxity Following GLP-1 Analog Therapy | Facial Skin Laxity | Not phased | ENROLLING_BY_INVITATION | 22 |
| NCT03899402 | Triple Therapy in T1DM | Type 1 Diabetes Mellitus | Phase 3 | Running, closed to new participants | 78 |
| NCT05779644 | Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Diabetes Mellitus | Metformin, Obesity, Abdominal | Not phased | Status not updated | 300 |
| NCT06468748 | The Effects of Semaglutide on Body Composition and Performance in Military Personnel | Obesity | Phase 4 | Withdrawn before enrolling | 0 — nobody enrolled |
| NCT07057310 | Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women | Obesity, Menopause | Phase 4 | ENROLLING_BY_INVITATION | 30 |
| NCT06924697 | Effect of Glucagon-like Peptide-1 (GLP-1) Receptor Agonist Stimulation on Smoking Consumption in Type 2 Diabetes Patients | Diabetes Mellitus, Type 2, Nicotine Dependence, Cigarettes | Not phased | ENROLLING_BY_INVITATION | 46 |
| NCT06298799 | GENETIC VARIABILITY TO GLP1 TREATMENT | Type 2 Diabetes, Obesity | Not phased | Status not updated | 400 |
—Read this
A trial count is not a verdict
These numbers describe how much has been formally studied in humans, not
whether something works or is safe for you. A compound can be tested for
one condition and sold for another — which is usually the story. This page
is automated aggregation from public registries; no physician has reviewed
it. Take anything here to a clinician.
Common questions about Semaglutide
How many human trials does Semaglutide have?
610. That is the number of registered interventional human studies we can find, each listed on this page with a link to its original record.
Is Semaglutide FDA approved?
Yes, but read the detail: FDA-approved for type 2 diabetes and chronic weight management. An approval for one condition is not an approval for everything it is marketed for.
What is Semaglutide actually being tested for?
Registered studies cover: glucose intolerance after a recent history of gestational diabetes, prediabetes, genetic predisposition. Compare that to what it is marketed for — the two lists are often different, which is the whole point of this page.
Where does this data come from?
ClinicalTrials.gov, the US public registry of clinical studies. We count interventional human studies only — observational studies are not evidence of effect. Every trial on this page links to its original record so you can check us rather than trust us.
Get told when this changes
One email a week: what moved in the research, and which claims the record doesn't support. Free, and you can leave in one click.