# MOTS-c

MOTS-c has 5 registered human trials. It is marketed for 3 different uses.

**In short**

- 5 registered human trials exist for MOTS-c.
- MOTS-c is not FDA-approved for any use.
- What has actually been studied: breast cancer, chronic kidney disease, bilateral vestibular hypofunction.
- Last checked against ClinicalTrials.gov on 2026-07-27.

## What it is sold for

- Metabolic health
- Endurance & performance
- Longevity

## What has actually been tested

- Breast Cancer
- Chronic Kidney Disease
- Bilateral Vestibular Hypofunction
- Bilateral Vestibular Deficiency
- Bilateral Vestibulopathy
- Gentamicin Ototoxicity
- Aminoglycoside Toxicity
- Vestibular Diseases
- Sensation Disorders
- Labyrinth Diseases
- Other Disorders of Vestibular Function
- Prediabetes
- Insulin Resistance
- Overweight/Obesity
- Kidney Disease, End-Stage
- Kidney Transplant
- Kidney
- Kidney Disease
- Renal Transplant

## Every trial on record

| Trial ID | Title | Condition | Phase | Status | Enrolled |
|---|---|---|---|---|---|
| [NCT04013568](https://clinicaltrials.gov/study/NCT04013568) | Exercise Post-Diagnosis of Breast Cancer | Breast Cancer | Not phased | COMPLETED | 62 |
| [NCT07438002](https://clinicaltrials.gov/study/NCT07438002) | Analysis of Effects of High-intensity Physical Exercise in Subjects With Dialyzed Chronic Kidney Disease and in Conservative Treatment | Chronic Kidney Disease | Not phased | RECRUITING | 50 |
| [NCT06500975](https://clinicaltrials.gov/study/NCT06500975) | Long Term Outcomes After Vestibular Implantation | Bilateral Vestibular Hypofunction, Bilateral Vestibular Deficiency | Not phased | RECRUITING | 32 |
| [NCT07505745](https://clinicaltrials.gov/study/NCT07505745) | MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity | Prediabetes, Insulin Resistance | Phase 2 | RECRUITING | 120 |
| [NCT07678073](https://clinicaltrials.gov/study/NCT07678073) | Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation | Kidney Disease, End-Stage, Kidney Transplant | Not phased | RECRUITING | 68 |

## Common questions

**How many human trials does MOTS-c have?**
5, each listed above with a link to its original record.

**Is MOTS-c FDA approved?**
No. It is not approved by the FDA for any indication.

**Where does this data come from?**
ClinicalTrials.gov. We count interventional human studies only. Every trial
links to its original record.

---

*Automated aggregation from public registries. Not medical advice. No physician
has reviewed this page. Source: https://www.whatsactuallyknown.com/compounds/mots-c*