# DSIP

DSIP has no registered human trials in the registries we track. It is marketed for 4 different uses.

**In short**

- No registered human trial exists for DSIP in the registries we track.
- DSIP is not FDA-approved for any use.
- Last checked against ClinicalTrials.gov on 2026-07-30.

## What it is

DSIP is a nine-amino-acid peptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) isolated in 1977 by Schoenenberger and Monnier from the cerebral venous blood of rabbits during induced slow-wave sleep. Its formal name is emideltide. Despite nearly fifty years of study, its receptor and its normal physiological function remain uncharacterised.

## Where the claims come from

The name is doing most of the marketing. A peptide isolated from the blood of sleeping animals suggests a natural sleep switch, and that story survives even though the molecule’s own biology was never pinned down. European and Soviet work in the 1980s and 1990s explored it for insomnia, opioid withdrawal and stress, and modern sellers cite that literature.

## What evidence exists outside the registry

Human studies were published before trial registration was standard, so the registry count of zero understates what exists. A 1992 double-blind study in chronic insomniacs and a 1998 open-label opioid-detoxification study are the most-cited. Open-label means everyone knew who received the compound, so it cannot separate an effect from expectation. Two further studies measured hormone responses rather than sleep outcomes, and one of those reported no effect.

**Sources for the above**

- [DSIP in chronic insomnia (Neuropsychobiology, 1992)](https://pubmed.ncbi.nlm.nih.gov/1299794/) — Double-blind study; among the few controlled human trials of DSIP.
- [DSIP in opioid detoxification (J Clin Psychopharmacol, 1998)](https://pubmed.ncbi.nlm.nih.gov/9617990/) — Open-label, no control group.
- [FDA — bulk drug substances nominated but withdrawn](https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks) — Emideltide (DSIP) appears in the withdrawn table, not the active Category 2 list.

## Approved for

Not approved by the FDA for any use. Nothing has been reviewed for safety, effectiveness or manufacturing quality.

## Studied for

No registered trial on ClinicalTrials.gov lists a studied condition for this compound. That is a gap in the registry, not a finding that it was tested and failed. Published human research may exist without a registry entry — registration only became standard in the mid-2000s.

## Marketed for

- Sleep quality
- Stress & cortisol
- Withdrawal support
- Pain

## What regulators have said

DSIP was nominated for use in pharmacy compounding and the nomination was withdrawn, so it is NOT on FDA's active list of substances that may present significant safety risks. FDA had published the concern below while it was under review.

FDA's own words: "Compounded drugs containing emideltide may pose risk for immunogenicity for certain routes of administration and may have complexities with regard to peptide-related impurities and API characterization. FDA has not identified safety-related information regarding emideltide for the proposed route of administration."

Source: US Food and Drug Administration — https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks
Checked 2026-07-30. This list changes.

This is a judgment about compounding and manufacturing, not a finding about whether DSIP has any effect.


## Every trial on record

No registered interventional human study found on ClinicalTrials.gov. That is not proof the compound does nothing, and not proof it was never given to a human — trial registration only became standard in the mid-2000s, so older published work often has no registry entry.

## Common questions

**How many human trials does DSIP have?**
None in the registries we track.

**Is DSIP FDA approved?**
No. It is not approved by the FDA for any indication.

**Where does this data come from?**
ClinicalTrials.gov. We count interventional human studies only. Every trial
links to its original record.

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*Automated aggregation from public registries. Not medical advice. No physician
has reviewed this page. Source: https://www.whatsactuallyknown.com/compounds/dsip*