# AOD-9604

AOD-9604 has no registered human trials in the registries we track. It is marketed for 3 different uses.

**In short**

- No registered human trial exists for AOD-9604 in the registries we track.
- AOD-9604 is not FDA-approved for any use.
- Last checked against ClinicalTrials.gov on 2026-07-28.

## What it is

AOD-9604 is a 16-amino-acid synthetic peptide corresponding to a fragment near the end of the human growth hormone molecule, with an added tyrosine. It is a fragment, not growth hormone: it was designed specifically to separate a fat-metabolism effect from the growth-promoting actions of the full hormone. It originated at Monash University in Australia and was developed commercially by Metabolic Pharmaceuticals.

## Where the claims come from

The claims trace to one research group and one abandoned obesity drug programme. The Monash work identified a growth hormone fragment that reduced weight gain and fat mass in obese mice, and Metabolic Pharmaceuticals developed analogues of it. AOD-9604 entered clinical development for obesity and that development was terminated in 2007. The compound was among those reviewed by the FDA's Pharmacy Compounding Advisory Committee, and it is on the World Anti-Doping Agency prohibited list.

## What evidence exists outside the registry

The core published evidence is rodent: a 2001 Endocrinology paper studied chronic administration in obese mice and reported reduced body weight and fat. Later published work is largely analytical chemistry for anti-doping detection, plus a rabbit joint model. Rodent and rabbit studies can establish a mechanism and an effect in that species; they cannot establish an effect in humans. The obesity trial results circulate mainly through secondary literature rather than a primary publication.

**Sources for the above**

- [Heffernan et al., Endocrinology 2001 — hGH lipolytic fragment in obese mice](https://pubmed.ncbi.nlm.nih.gov/11713213/) — The core preclinical paper; a mouse model.
- [FDA Pharmacy Compounding Advisory Committee briefing document](https://www.fda.gov/media/183819/download) — FDA's own structural description of the fragment.
- [AOD-9604 and the WADA hGH isoform immunoassay](https://pubmed.ncbi.nlm.nih.gov/24124033/) — Anti-doping detection work; status in sport testing.

## What it is sold for

- Fat loss
- Weight management
- Cartilage repair

## What has actually been tested

Nothing. No registered human trial exists in the registries we track.

## Every trial on record

No registered interventional human study found. That is not proof the compound does nothing — it means nobody has formally checked.

## Common questions

**How many human trials does AOD-9604 have?**
None in the registries we track.

**Is AOD-9604 FDA approved?**
No. It is not approved by the FDA for any indication.

**Where does this data come from?**
ClinicalTrials.gov. We count interventional human studies only. Every trial
links to its original record.

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*Automated aggregation from public registries. Not medical advice. No physician
has reviewed this page. Source: https://www.whatsactuallyknown.com/compounds/aod-9604*